The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Somato-motor inhibitory processing in humans: a study with MEG and ERP.

The go/nogo task is a useful paradigm for recording event-related potentials (ERPs) to investigate the neural mechanisms of response inhibition. In nogo trials, a negative deflection at around 140-300 ms (N2), which has been called the 'nogo potential', is elicited at the frontocentral electrodes, compared with ERPs recorded in go trials. In the present study, we investigated the generators of nogo potentials by recording ERPs and by using magnetoencephalography (MEG) simultaneously during somatosensory go/nogo tasks to elucidate the regions involved in generating nogo potentials. ERP data revealed that the amplitude of the nogo-N140 component, which peaked at about 155 ms from frontocentral electrodes, was significantly more negative than that of go-N140. MEG data revealed that a long-latency response peaking at approximately 160 ms, termed nogo-M140 and corresponding to nogo-N140, was recorded in only nogo trials. The equivalent current dipole of nogo-M140 was estimated to lie around the posterior part of the inferior frontal sulci in the prefrontal cortex. These results revealed that both nogo-N140 and nogo-M140 evoked by somatosensory go/nogo tasks were related to the neural activity generated from the prefrontal cortex. Our findings combining MEG and ERPs clarified the spatial and temporal processing related to somato-motor inhibition caused in the posterior part of the inferior frontal sulci in the prefrontal cortex in humans.[1]

References

  1. Somato-motor inhibitory processing in humans: a study with MEG and ERP. Nakata, H., Inui, K., Wasaka, T., Akatsuka, K., Kakigi, R. Eur. J. Neurosci. (2005) [Pubmed]
 
WikiGenes - Universities