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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing.

Fission yeast centromeric repeats are transcribed into small interfering RNA (siRNA) precursors (pre-siRNAs), which are processed by Dicer to direct heterochromatin formation. Recently, Rpb1 and Rpb2 subunits of RNA polymerase II (RNA Pol II) were shown to mediate RNA interference (RNAi)-directed chromatin modification but did not affect pre-siRNA levels. Here we show that another Pol II subunit, Rpb7 has a specific role in pre-siRNA transcription. We define a centromeric pre-siRNA promoter from which initiation is exquisitely sensitive to the rpb7-G150D mutation. In contrast to other Pol II subunits, Rpb7 promotes pre-siRNA transcription required for RNAi-directed chromatin silencing.[1]

References

  1. RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing. Djupedal, I., Portoso, M., Spåhr, H., Bonilla, C., Gustafsson, C.M., Allshire, R.C., Ekwall, K. Genes Dev. (2005) [Pubmed]
 
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