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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma.

Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers.[1]

References

  1. t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma. Fenton, J.A., Schuuring, E., Barrans, S.L., Banham, A.H., Rollinson, S.J., Morgan, G.J., Jack, A.S., van Krieken, J.H., Kluin, P.M. Genes Chromosomes Cancer (2006) [Pubmed]
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