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Gene Review

FOXP1  -  forkhead box P1

Homo sapiens

Synonyms: 12CC4, Forkhead box protein P1, HSPC215, MFH, Mac-1-regulated forkhead, ...
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Disease relevance of FOXP1

  • Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma [1].
  • EXPERIMENTAL DESIGN: We have therefore investigated the pattern of FOXP1 expression in whole sections from normal (n = 16) and neoplastic (n = 90) breast tissues and correlated the level of expression in 283 invasive breast carcinomas on tissue microarrays with clinicopathological factors and survival [2].
  • The FOXP1 gene, which maps to 3p14, shows common loss of heterozygosity in breast tumors and is a candidate tumor suppressor gene [2].
  • The specific colocalization of FoxP1 and FoxP2 found in several structures in the bird and human brain predicts that mutations in FOXP1 could also be related to speech disorders [3].
  • T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma [4].
  • These transcripts and the smaller protein isoforms were induced as a consequence of normal B-cell activation, which thus represents an additional mechanism for up-regulating FOXP1 expression in lymphomas [5].

High impact information on FOXP1


Chemical compound and disease context of FOXP1


Biological context of FOXP1


Anatomical context of FOXP1

  • Unlike normal breast, there was common coexpression of FOXP1 and ER in cell lines and tumors, but no 17beta-estradiol (10(-9) m) regulation of FOXP1 in MCF-7 cells was demonstrated [2].
  • RESULTS: Expression of FOXP1 was significantly positively associated with ER (P = 0.03) and negatively with epidermal growth factor receptor (P = 0.01) but no association with age (P = 0.91), lymph node status (P = 0.94), size (P = 0.76), or grade (P = 0.22) [2].
  • A role for FOX TFs was supported further by expression of FOXC1, C2, P1, P4, and O1A in failing human cardiac myocytes at levels similar to established hypertrophic TFs and by abundant FOXP1 protein in failing human cardiac myocyte nuclei [12].
  • Proliferative endometrium showed predominantly nuclear localization of FOXP1, while exclusively weak cytoplasmic staining was present in the secretory phase [9].
  • Recently, it was also found that FOXP1 rearrangements and expression of its protein occur in mucosa-associated lymphoid tissue (MALT) lymphomas [13].

Associations of FOXP1 with chemical compounds

  • In some cases the strength of Foxp1 repression is mediated by the polyglutamine domain [14].
  • This review highlights the role of transcription factors in monocyte differentiation and describes how integrin engagement orchestrates monocyte differentiation signals by regulating the expression of the forkhead transcription factor Foxp1, which functions as a transcriptional repressor of the macrophage colony-stimulating factor receptor c-fms [15].

Other interactions of FOXP1

  • In support of this idea, we find that FOXP1 and FOXP2 expression patterns in human fetal brain are strikingly similar to those in the songbird, including localization to subcortical structures that function in sensorimotor integration and the control of skilled, coordinated movement [3].
  • Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas [2].
  • This study identifies FOXP1 as a new translocation partner of IGH in a site-dependent subset of MALT lymphomas [4].
  • Long-distance inverse polymerase chain reaction identified FOXP1 as the partner gene on chromosome 3 [4].
  • Tumors with exclusively cytoplasmic expression of FOXP1 were linked with deep myometrial invasion and hypoxia-inducible factors 1alpha (HIF-1alpha) expression [9].

Analytical, diagnostic and therapeutic context of FOXP1


  1. Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. Banham, A.H., Connors, J.M., Brown, P.J., Cordell, J.L., Ott, G., Sreenivasan, G., Farinha, P., Horsman, D.E., Gascoyne, R.D. Clin. Cancer Res. (2005) [Pubmed]
  2. Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas. Fox, S.B., Brown, P., Han, C., Ashe, S., Leek, R.D., Harris, A.L., Banham, A.H. Clin. Cancer Res. (2004) [Pubmed]
  3. Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. Teramitsu, I., Kudo, L.C., London, S.E., Geschwind, D.H., White, S.A. J. Neurosci. (2004) [Pubmed]
  4. T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. Streubel, B., Vinatzer, U., Lamprecht, A., Raderer, M., Chott, A. Leukemia (2005) [Pubmed]
  5. Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL. Brown, P.J., Ashe, S.L., Leich, E., Burek, C., Barrans, S., Fenton, J.A., Jack, A.S., Pulford, K., Rosenwald, A., Banham, A.H. Blood (2008) [Pubmed]
  6. DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain. Li, C., Tucker, P.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  7. Strong expression of FOXP1 identifies a distinct subset of diffuse large B-cell lymphoma (DLBCL) patients with poor outcome. Barrans, S.L., Fenton, J.A., Banham, A., Owen, R.G., Jack, A.S. Blood (2004) [Pubmed]
  8. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. Banham, A.H., Beasley, N., Campo, E., Fernandez, P.L., Fidler, C., Gatter, K., Jones, M., Mason, D.Y., Prime, J.E., Trougouboff, P., Wood, K., Cordell, J.L. Cancer Res. (2001) [Pubmed]
  9. Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression. Giatromanolaki, A., Koukourakis, M.I., Sivridis, E., Gatter, K.C., Harris, A.L., Banham, A.H. Mod. Pathol. (2006) [Pubmed]
  10. The FOXP1 Transcription Factor is Expressed in the Majority of Follicular Lymphomas but is Rarely Expressed in Classical and Lymphocyte Predominant Hodgkin's Lymphoma. Brown, P., Marafioti, T., Kusec, R., Banham, A.H. Journal of molecular histology. (2005) [Pubmed]
  11. t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma. Fenton, J.A., Schuuring, E., Barrans, S.L., Banham, A.H., Rollinson, S.J., Morgan, G.J., Jack, A.S., van Krieken, J.H., Kluin, P.M. Genes Chromosomes Cancer (2006) [Pubmed]
  12. Transcriptional genomics associates FOX transcription factors with human heart failure. Hannenhalli, S., Putt, M.E., Gilmore, J.M., Wang, J., Parmacek, M.S., Epstein, J.A., Morrisey, E.E., Margulies, K.B., Cappola, T.P. Circulation (2006) [Pubmed]
  13. Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphoma. Sagaert, X., de Paepe, P., Libbrecht, L., Vanhentenrijk, V., Verhoef, G., Thomas, J., Wlodarska, I., De Wolf-Peeters, C. J. Clin. Oncol. (2006) [Pubmed]
  14. Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. Wang, B., Lin, D., Li, C., Tucker, P. J. Biol. Chem. (2003) [Pubmed]
  15. Integrin signals, transcription factors, and monocyte differentiation. Shi, C., Simon, D.I. Trends Cardiovasc. Med. (2006) [Pubmed]
  16. FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations. Wlodarska, I., Veyt, E., De Paepe, P., Vandenberghe, P., Nooijen, P., Theate, I., Michaux, L., Sagaert, X., Marynen, P., Hagemeijer, A., De Wolf-Peeters, C. Leukemia (2005) [Pubmed]
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