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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase.

The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design.[1]

References

  1. Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase. Almassy, R.J., Janson, C.A., Kan, C.C., Hostomska, Z. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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