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Gene Review

purN  -  phosphoribosylglycinamide formyltransferase 1

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2496, JW2485, ade
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Disease relevance of purN


High impact information on purN


Chemical compound and disease context of purN


Biological context of purN

  • Immediately downstream from the purN gene of the purMN operon is a region of dyad symmetry capable of forming a hairpin stem and loop structure characteristic of a rho-independent terminator [1].
  • The deduced amino acid sequence of the human and avian polyproteins show extensive sequence homologies to the bacterial purD, purM, and purN encoded proteins [7].

Associations of purN with chemical compounds


Other interactions of purN

  • Based on polarity studies, the expression of the purN gene originates from the purM control region and thus forms a purMN operon [1].


  1. Identification and nucleotide sequence of a gene encoding 5'-phosphoribosylglycinamide transformylase in Escherichia coli K12. Smith, J.M., Daum, H.A. J. Biol. Chem. (1987) [Pubmed]
  2. Isolation and characterization of cDNA clones for rat liver 10-formyltetrahydrofolate dehydrogenase. Cook, R.J., Lloyd, R.S., Wagner, C. J. Biol. Chem. (1991) [Pubmed]
  3. Creating multiple-crossover DNA libraries independent of sequence identity. Lutz, S., Ostermeier, M., Moore, G.L., Maranas, C.D., Benkovic, S.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Assembly of an active enzyme by the linkage of two protein modules. Nixon, A.E., Warren, M.S., Benkovic, S.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  5. Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase. Almassy, R.J., Janson, C.A., Kan, C.C., Hostomska, Z. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase. Inglese, J., Johnson, D.L., Shiau, A., Smith, J.M., Benkovic, S.J. Biochemistry (1990) [Pubmed]
  7. De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli. Aimi, J., Qiu, H., Williams, J., Zalkin, H., Dixon, J.E. Nucleic Acids Res. (1990) [Pubmed]
  8. Formyl phosphate: a proposed intermediate in the reaction catalyzed by Escherichia coli PurT GAR transformylase. Marolewski, A.E., Mattia, K.M., Warren, M.S., Benkovic, S.J. Biochemistry (1997) [Pubmed]
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