Chemical Compound Review:
Folacin (2S)-2-[[4-[(2-amino-4-oxo- 1H-pteridin-6...
Synonyms:
Acifolic, Folaemin, Folvite, Folate, Vitamin M, ...
Willett,
Leane Hoey,
John M. Scott,
Hunter,
Erika Vandette,
Cole,
Verschuren,
Cliona A. Flynn,
Stein Emil Vollset,
Duan,
Colditz,
Helga Refsum,
Charles Fuchs,
Rosner,
Colditz,
Jj Strain,
Godfrey P. Oakley,
Manson,
Haakon E. Meyer,
Nader Rifai,
Gaia Bistulfi,
Adrian Dunne,
Brian Wolpin,
Rimm,
Chan,
Ed Giovannucci,
Kristina Pentieva,
Deeley,
Meir J. Stampfer,
Willett,
Helene McNulty,
Cynthia Thomson,
Anne M. Molloy,
Sampson,
De Bree,
Barbara Cochrane,
Jo Ann Manson,
Clara Gram Gjesdal,
Dominic J. Smiraglia,
Per Magne Ueland,
Zhang,
Giovannucci,
Hankinson,
Jing Ma,
Hennekens,
Kromhout,
Kluijtmans,
Westlake,
Eva Schernhammer,
Shea,
Grethe S. Tell,
Blom,
Mattson,
Sei-Ichi Matsui,
Nadina Askin,
Stampfer,
Hu,
Mattson,
Mary Ward,
Speizer,
- The absence of a relation between the periconceptional use of vitamins and neural-tube defects. National Institute of Child Health and Human Development Neural Tube Defects Study Group. Mills, J.L., Rhoads, G.G., Simpson, J.L., Cunningham, G.C., Conley, M.R., Lassman, M.R., Walden, M.E., Depp, O.R., Hoffman, H.J. N. Engl. J. Med. (1989)
- A point mutation in the FMR-1 gene associated with fragile X mental retardation. De Boulle, K., Verkerk, A.J., Reyniers, E., Vits, L., Hendrickx, J., Van Roy, B., Van den Bos, F., de Graaff, E., Oostra, B.A., Willems, P.J. Nat. Genet. (1993)
- Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity. Freeman, J.M., Finkelstein, J.D., Mudd, S.H. N. Engl. J. Med. (1975)
- Folate levels in inflammatory bowel disease. Longstreth, G.F., Green, R. N. Engl. J. Med. (1982)
- ZTP (5-amino 4-imidazole carboxamide riboside 5'-triphosphate): a proposed alarmone for 10-formyl-tetrahydrofolate deficiency. Bochner, B.R., Ames, B.N. Cell (1982)
- When will we eliminate folic acid-preventable spina bifida? Oakley, G.P. Epidemiology (2007)
- Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. Schernhammer, E., Wolpin, B., Rifai, N., Cochrane, B., Manson, J.A., Ma, J., Giovannucci, E., Thomson, C., Stampfer, M.J., Fuchs, C. Cancer Res. (2007)
- Folate, but not vitamin B-12 status, predicts respiratory morbidity in north Indian children. Strand, T.A., Taneja, S., Bhandari, N., Refsum, H., Ueland, P.M., Gjessing, H.K., Bahl, R., Schneede, J., Bhan, M.K., Sommerfelt, H. Am. J. Clin. Nutr. (2007)
- Folate supplementation limits the aggressiveness of glioma via the remethylation of DNA repeats element and genes governing apoptosis and proliferation. Hervouet, E., Debien, E., Campion, L., Charbord, J., Menanteau, J., Vallette, F.M., Cartron, P.F. Clin. Cancer Res. (2009)
- Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions. Pilsner, J.R., Liu, X., Ahsan, H., Ilievski, V., Slavkovich, V., Levy, D., Factor-Litvak, P., Graziano, J.H., Gamble, M.V. Environ. Health Perspect. (2009)
- Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Mattson, M.P., Chan, S.L., Duan, W. Physiol. Rev. (2002)
- Folate deficiency and restless-legs syndrome in pregnancy. Botez, M.I., Lambert, B. N. Engl. J. Med. (1977)
- A prospective study of folate intake and the risk of breast cancer. Zhang, S., Hunter, D.J., Hankinson, S.E., Giovannucci, E.L., Rosner, B.A., Colditz, G.A., Speizer, F.E., Willett, W.C. JAMA (1999)
- Prepregnant weight in relation to risk of neural tube defects. Werler, M.M., Louik, C., Shapiro, S., Mitchell, A.A. JAMA (1996)
- Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Mattson, M.P., Shea, T.B. Trends Neurosci. (2003)
- Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Deeley, R.G., Westlake, C., Cole, S.P. Physiol. Rev. (2006)
- Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Qiu, A., Jansen, M., Sakaris, A., Min, S.H., Chattopadhyay, S., Tsai, E., Sandoval, C., Zhao, R., Akabas, M.H., Goldman, I.D. Cell (2006)
- Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Piedrahita, J.A., Oetama, B., Bennett, G.D., van Waes, J., Kamen, B.A., Richardson, J., Lacey, S.W., Anderson, R.G., Finnell, R.H. Nat. Genet. (1999)
- Inositol prevents folate-resistant neural tube defects in the mouse. Greene, N.D., Copp, A.J. Nat. Med. (1997)
- Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. Rimm, E.B., Willett, W.C., Hu, F.B., Sampson, L., Colditz, G.A., Manson, J.E., Hennekens, C., Stampfer, M.J. JAMA (1998)
- Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent. Allegra, C.J., Kovacs, J.A., Drake, J.C., Swan, J.C., Chabner, B.A., Masur, H. J. Exp. Med. (1987)
- Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells. Genestier, L., Paillot, R., Fournel, S., Ferraro, C., Miossec, P., Revillard, J.P. J. Clin. Invest. (1998)
- Linkage of markers controlling consecutive biochemical steps in CHO cells as demonstrated by chromosome transfer. Spandidos, D.A., Siminovitch, L. Cell (1977)
- Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat. Yu, S., Mangelsdorf, M., Hewett, D., Hobson, L., Baker, E., Eyre, H.J., Lapsys, N., Le Paslier, D., Doggett, N.A., Sutherland, G.R., Richards, R.I. Cell (1997)
- Gene replacement in parasitic protozoa. Cruz, A., Beverley, S.M. Nature (1990)
- Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. De Bree, A., Verschuren, W.M., Kromhout, D., Kluijtmans, L.A., Blom, H.J. Pharmacol. Rev. (2002)
- Folate-induced remission in aplastic anemia with familial defect of cellular folate uptake. Branda, R.F., Moldow, C.F., MacArthur, J.R., Wintrobe, M.M., Anthony, B.K., Jacob, H.S. N. Engl. J. Med. (1978)
- Folate and aplasia of bone marrow. Babior, B.M. N. Engl. J. Med. (1978)
- Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria. Eilers, M., Schatz, G. Nature (1986)
- Folate conjugase: two separate activities in human jejunum. Reisenauer, A.M., Krumdieck, C.L., Halsted, C.H. Science (1977)
- The effect of folic acid fortification on plasma folate and total homocysteine concentrations. Jacques, P.F., Selhub, J., Bostom, A.G., Wilson, P.W., Rosenberg, I.H. N. Engl. J. Med. (1999)
- Detection of a milk factor that facilitates folate uptake by intestinal cells. Colman, N., Hettiarachchy, N., Herbert, V. Science (1981)
- Mechanisms of resistance of malaria parasites to antifolates. Gregson, A., Plowe, C.V. Pharmacol. Rev. (2005)
- Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. Selhub, J., Jacques, P.F., Wilson, P.W., Rush, D., Rosenberg, I.H. JAMA (1993)
- The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Ebisch, I.M., Thomas, C.M., Peters, W.H., Braat, D.D., Steegers-Theunissen, R.P. Hum. Reprod. Update (2007)
- Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study. Gjesdal, C.G., Vollset, S.E., Ueland, P.M., Refsum, H., Meyer, H.E., Tell, G.S. J. Bone Miner. Res. (2007)
- Cobalamin and folate status in infants and young children in a low-to-middle income community in India. Taneja, S., Bhandari, N., Strand, T.A., Sommerfelt, H., Refsum, H., Ueland, P.M., Schneede, J., Bahl, R., Bhan, M.K. Am. J. Clin. Nutr. (2007)
- Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults. Hoey, L., McNulty, H., Askin, N., Dunne, A., Ward, M., Pentieva, K., Strain, J., Molloy, A.M., Flynn, C.A., Scott, J.M. Am. J. Clin. Nutr. (2007)
- Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation. Baggott, J.E., Morgan, S.L. Arthritis Rheum. (2009)
- Higher liposomal membrane fluidity enhances the in vitro antitumor activity of folate-targeted liposomal mitoxantrone. Kawano, K., Onose, E., Hattori, Y., Maitani, Y. Mol. Pharm. (2009)
- Folate and one-carbon metabolism and its impact on aberrant DNA methylation in cancer. Liu, J.J., Ward, R.L. Adv. Genet. (2010)
- Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE. Parrish, J.E., Oostra, B.A., Verkerk, A.J., Richards, C.S., Reynolds, J., Spikes, A.S., Shaffer, L.G., Nelson, D.L. Nat. Genet. (1994)
- Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Ting, S.B., Wilanowski, T., Auden, A., Hall, M., Voss, A.K., Thomas, T., Parekh, V., Cunningham, J.M., Jane, S.M. Nat. Med. (2003)
- A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? van der Put, N.M., Gabreëls, F., Stevens, E.M., Smeitink, J.A., Trijbels, F.J., Eskes, T.K., van den Heuvel, L.P., Blom, H.J. Am. J. Hum. Genet. (1998)
- Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome. Hobbs, C.A., Sherman, S.L., Yi, P., Hopkins, S.E., Torfs, C.P., Hine, R.J., Pogribna, M., Rozen, R., James, S.J. Am. J. Hum. Genet. (2000)
- Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Carter, M., Chen, X., Slowinska, B., Minnerath, S., Glickstein, S., Shi, L., Campagne, F., Weinstein, H., Ross, M.E. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Regulation of one-carbon metabolism in Arabidopsis: the N-terminal regulatory domain of cystathionine gamma-synthase is cleaved in response to folate starvation. Loizeau, K., Gambonnet, B., Zhang, G.F., Curien, G., Jabrin, S., Van Der Straeten, D., Lambert, W.E., Rébeillé, F., Ravanel, S. Plant Physiol. (2007)
- Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells. Ashokkumar, B., Mohammed, Z.M., Vaziri, N.D., Said, H.M. Am. J. Clin. Nutr. (2007)
- The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis. Ifergan, I., Jansen, G., Assaraf, Y.G. J. Biol. Chem. (2008)
- Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells. Bistulfi, G., Vandette, E., Matsui, S., Smiraglia, D.J. BMC Biol. (2010)
- Folate levels and neural tube defects. Implications for prevention. Daly, L.E., Kirke, P.N., Molloy, A., Weir, D.G., Scott, J.M. JAMA (1995)
- Serum folate and risk of fatal coronary heart disease. Morrison, H.I., Schaubel, D., Desmeules, M., Wigle, D.T. JAMA (1996)
- Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. Singletary, K.W., Gapstur, S.M. JAMA (2001)
- Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Report of a preliminary randomized, double-blind intervention trial. Heimburger, D.C., Alexander, C.B., Birch, R., Butterworth, C.E., Bailey, W.C., Krumdieck, C.L. JAMA (1988)