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Eichele, T. et al.

Assessing the spatiotemporal evolution of neuronal activation with single-trial event-related potentials and functional MRI.

The brain acts as an integrated information processing system, which methods in cognitive neuroscience have so far depicted in a fragmented fashion. Here, we propose a simple and robust way to integrate functional MRI (fMRI) with single trial event-related potentials ( ERP) to provide a more complete spatiotemporal characterization of evoked responses in the human brain. The idea behind the approach is to find brain regions whose fMRI responses can be predicted by paradigm-induced amplitude modulations of simultaneously acquired single trial ERPs. The method was used to study a variant of a two-stimulus auditory target detection (odd-ball) paradigm that manipulated predictability through alternations of stimulus sequences with random or regular target-to-target intervals. In addition to electrophysiologic and hemodynamic evoked responses to auditory targets per se, single-trial modulations were expressed during the latencies of the P2 (170-ms), N2 (200-ms), and P3 (320-ms) components and predicted spatially separated fMRI activation patterns. These spatiotemporal matches, i.e., the prediction of hemodynamic activation by time-variant information from single trial ERPs, permit inferences about regional responses using fMRI with the temporal resolution provided by electrophysiology.[1]

References

Assessing the spatiotemporal evolution of neuronal activation with single-trial event-related potentials and functional MRI. Eichele, T., Specht, K., Moosmann, M., Jongsma, M.L., Quiroga, R.Q., Nordby, H., Hugdahl, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]

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