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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Neurosciences

  • The kinetic parameters of the model fits were similar to those of GH3 pituitary cells (Horn, R., and C. A. Vandenberg. 1984. Journal of General Physiology. 84:505-534) and N1E115 neuroblastoma cells (Aldrich, R. W., and C. F. Stevens. Journal of Neuroscience. 7:418-431) [1].
  • In ischemia/reperfusion injury, free radicals cause synaptosomal membrane protein and lipid oxidation that is prevented by the free radical scavenger N-tert-butyl-alpha-phenylnitrone (Hall N. C. et al. (1995) Neuroscience 64, 81-89; 69, 591-600) [2].
  • In a recent study [Gordon et al., Neuroscience, 69 (1995) 345-349.] evaluating interaction between the GABAB agonist baclofen and opiates with respect to postoperative analgesia we found that females receiving pentazocine for the treatment of postoperative pain showed better analgesia than did males receiving similar treatment [3].
  • INTERVENTION: Serial dilutions of the serum disclosed hyperprolactinemia of 280,000 ng/ml, establishing the presence of the "high-dose hook effect." Treatment with pergolide (Permax; Athena Neurosciences, S. San Francisco, CA) decreased tumor size and lowered serum prolactin by more than 99% [4].
  • Arnold Pick (1851-1924) provided the first description of the neurodegenerative disease associated with his name; but his importance to the field of neuroscience goes far beyond this eponymous gift [5].

Psychiatry related information on Neurosciences


High impact information on Neurosciences


Chemical compound and disease context of Neurosciences


Biological context of Neurosciences


Anatomical context of Neurosciences


Associations of Neurosciences with chemical compounds

  • In 1996, as an innovation for the UK, the Wellcome Trust set up two 'American style' four-year PhD programmes in neuroscience, with an initial year of broad training followed by a three-year PhD [31].
  • Recent reports have overturned a series of dogmas that have been well entrenched in the neuroscience literature concerning NMDA-type glutamate receptors (NMDARs) [32].
  • Methylated cytosine and the brain: a new base for neuroscience [33].
  • Art and neuroscience: how the brain sees Vermeer's Woman Holding a Balance [34].
  • Sympathetic neurons cultured in defined medium do not develop the ability to produce acetylcholine, as do neurons grown with serum supplementation (lacovitti, L., M. I. Johnson, T. H. Joh, and R. P. Bunge (1982) Neuroscience 7:2225-2239; Wolinsky, E. J., S. C. Landis, and P. H. Patterson (1985) J. Neurosci. 5: 1497-1508) [35].

Gene context of Neurosciences

  • Currently, diagnoses of attention deficit hyperactivity disorder (ADHD) and hyperkinetic disorder (HKD) are made on the basis of phenomenology, but information is accumulating from the neurosciences about the biological bases of these disorders [36].
  • TNF and related molecules: trends in neuroscience and clinical applications [37].
  • Stimulated by the fairly recent recognition of receptor subtypes (A and B), and the development of receptor-specific antagonists, CCK research has been advancing rapidly; and its potential importance to psychiatric neuroscience has been increasingly recognized [38].
  • The rhythm was phase delayed by 6-8 h compared with the reported rhythm of Per1 mRNA in the rat SCN [L. Yan et al. Neuroscience 94 (1999) 141] [39].
  • According to presenters at the 1999 Society for Neuroscience meeting, this may result from a novel activity-dependent or NR2B-selective mechanism of action [345079] [40].

Analytical, diagnostic and therapeutic context of Neurosciences


  1. Kinetic analysis of single sodium channels from canine cardiac Purkinje cells. Scanley, B.E., Hanck, D.A., Chay, T., Fozzard, H.A. J. Gen. Physiol. (1990) [Pubmed]
  2. Effect of 2-cyclohexene-1-one-induced glutathione diminution on ischemia/reperfusion-induced alterations in the physical state of brain synaptosomal membrane proteins and lipids. Hall, N.C., Carney, J.M., Plante, O.J., Cheng, M., Butterfield, D.A. Neuroscience (1997) [Pubmed]
  3. Gender difference in analgesic response to the kappa-opioid pentazocine. Gear, R.W., Gordon, N.C., Heller, P.H., Paul, S., Miaskowski, C., Levine, J.D. Neurosci. Lett. (1996) [Pubmed]
  4. Giant pituitary prolactinoma with falsely low serum prolactin: the pitfall of the "high-dose hook effect": case report. Barkan, A.L., Chandler, W.F. Neurosurgery (1998) [Pubmed]
  5. Arnold Pick's concept of dementia. Spatt, J. Cortex; a journal devoted to the study of the nervous system and behavior. (2003) [Pubmed]
  6. Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation. Almkvist, O., Basun, H., Wagner, S.L., Rowe, B.A., Wahlund, L.O., Lannfelt, L. Arch. Neurol. (1997) [Pubmed]
  7. Weight gain during long-term treatment of obsessive-compulsive disorder: a prospective comparison between serotonin reuptake inhibitors. Maina, G., Albert, U., Salvi, V., Bogetto, F. The Journal of clinical psychiatry. (2004) [Pubmed]
  8. Ibotenic acid lesions of prefrontal cortex do not prevent expression of behavioral sensitization to amphetamine. Li, Y., Wolf, M.E. Behav. Brain Res. (1997) [Pubmed]
  9. The many varieties of catatonia. Fink, M., Taylor, M.A. European archives of psychiatry and clinical neuroscience. (2001) [Pubmed]
  10. Shared representations between self and other: a social cognitive neuroscience view. Decety, J., Sommerville, J.A. Trends Cogn. Sci. (Regul. Ed.) (2003) [Pubmed]
  11. Neuroscience meeting draws fire over Dalai Lama lecture. Cyranoski, D. Nat. Med. (2005) [Pubmed]
  12. Neuroscience. Sharp edges into new terrain. Interview by Andrew Lawler. Sharp, P. Science (2001) [Pubmed]
  13. Neuroscience. Parkin and its substrates. Haass, C., Kahle, P.J. Science (2001) [Pubmed]
  14. Neuroscience. A kinase to dampen the effects of cociane? Gupta, A., Tsai, L.H. Science (2001) [Pubmed]
  15. Neuroscience. Neural net contest draws online crowd. MacNeil, J.S. Science (2000) [Pubmed]
  16. Diazepam reduces brain lesion size in a photothrombotic model of focal ischemia in rats. Aerden, L.A., Kessels, F.A., Rutten, B.P., Lodder, J., Steinbusch, H.W. Neurosci. Lett. (2004) [Pubmed]
  17. Clinical pharmacology of CNS 1102 in volunteers. Muir, K.W., Grosset, D.G., Lees, K.R. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
  18. The anatomy of the basal ganglia and Parkinson's disease: a review. Lee, T.K., Chau, R., Leong, S.K. Singapore medical journal. (1995) [Pubmed]
  19. Measurement of basal forebrain atrophy in Alzheimer's disease using MRI. Teipel, S.J., Flatz, W.H., Heinsen, H., Bokde, A.L., Schoenberg, S.O., Stöckel, S., Dietrich, O., Reiser, M.F., Möller, H.J., Hampel, H. Brain (2005) [Pubmed]
  20. Remission: Today's Target in the Treatment of Mood and Anxiety Disorders. Nemeroff, C.B. Psychopharmacology bulletin. (2002) [Pubmed]
  21. Presynaptic induction and expression of NMDA-dependent LTP. Paré, D. Trends Neurosci. (2004) [Pubmed]
  22. Serotonin neurotoxicity: implications for cognitive neuroscience and neurology. D'Esposito, M. Neurology (1998) [Pubmed]
  23. Neuroimmunology of gangliosides in human neurons and glial cells in culture. Kim, S.U., Moretto, G., Lee, V., Yu, R.K. J. Neurosci. Res. (1986) [Pubmed]
  24. High-throughput immunoblotting identifies biotin-dependent signaling proteins in HepG2 hepatocarcinoma cells. Rodriguez-Melendez, R., Griffin, J.B., Sarath, G., Zempleni, J. J. Nutr. (2005) [Pubmed]
  25. Impact of neonatal kainate treatment on hippocampal insulin-like growth factor receptors. Doré, S., Kar, S., Chabot, J.G., Quirion, R. Neuroscience (1999) [Pubmed]
  26. Developing concepts in neural stem cells. Dietrich, J., Easterday, M.C. Trends Neurosci. (2002) [Pubmed]
  27. Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system. Andersson, P.B., Perry, V.H., Gordon, S. J. Exp. Med. (1992) [Pubmed]
  28. Neuroleptic-induced hypothermia associated with amelioration of psychosis in schizophrenia. Heh, C.W., Herrera, J., DeMet, E., Potkin, S., Costa, J., Sramek, J., Hazlett, E., Buchsbaum, M.S. Neuropsychopharmacology (1988) [Pubmed]
  29. Monocular deprivation decreases brain-derived neurotrophic factor immunoreactivity in the rat visual cortex. Rossi, F.M., Bozzi, Y., Pizzorusso, T., Maffei, L. Neuroscience (1999) [Pubmed]
  30. Cell-cell coupling between CO2-excited neurons in the dorsal medulla oblongata. Huang, R.Q., Erlichman, J.S., Dean, J.B. Neuroscience (1997) [Pubmed]
  31. Four-year PhDs in neuroscience: an assessment after four years. Rawlins, N., Akerman, C.J., Andolina, I., Blakemore, S.J., Mrsic-Flogel, T., Attwell, D. Trends Neurosci. (2000) [Pubmed]
  32. NMDA receptors, glial cells, and clinical medicine. Lipton, S.A. Neuron (2006) [Pubmed]
  33. Methylated cytosine and the brain: a new base for neuroscience. Tucker, K.L. Neuron (2001) [Pubmed]
  34. Art and neuroscience: how the brain sees Vermeer's Woman Holding a Balance. Espinel, C.H. Lancet (1998) [Pubmed]
  35. Rat serum contains a developmentally regulated cholinergic inducing activity. Wolinsky, E.J., Patterson, P.H. J. Neurosci. (1985) [Pubmed]
  36. Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder. Swanson, J., Castellanos, F.X., Murias, M., LaHoste, G., Kennedy, J. Curr. Opin. Neurobiol. (1998) [Pubmed]
  37. TNF and related molecules: trends in neuroscience and clinical applications. Probert, L., Selmaj, K. J. Neuroimmunol. (1997) [Pubmed]
  38. Cholecystokinin in psychiatric research: a time for cautious excitement. Abelson, J.L. Journal of psychiatric research. (1995) [Pubmed]
  39. The circadian rhythm of Per1 gene product in the rat suprachiasmatic nucleus and its modulation by seasonal changes in daylength. Sumová, A., Sládek, M., Jác, M., Illnerová, H. Brain Res. (2002) [Pubmed]
  40. CP-101606 Pfizer Inc. Chazot, P.L. Current opinion in investigational drugs (London, England : 2000) (2000) [Pubmed]
  41. Search for correlations between serotonin 5-HT1A receptor expression and cognitive functions--a strategy in translational psychopharmacology. Borg, J., Andrée, B., Lundberg, J., Halldin, C., Farde, L. Psychopharmacology (Berl.) (2006) [Pubmed]
  42. Receptor autoradiography and 2-deoxyglucose techniques in neuroscience. Wiederhold, K.H., Palacios, J.M. Journal of microscopy. (1990) [Pubmed]
  43. Patterns of cyclic AMP formation by coexpressed D1 and D2L dopamine receptors in HEK 293 cells. Sakolsky, D.J., Ashby, B. Recept. Channels (2001) [Pubmed]
  44. Measuring the impact of multiple sclerosis on psychosocial functioning: the development of a new self-efficacy scale. Airlie, J., Baker, G.A., Smith, S.J., Young, C.A. Clinical rehabilitation. (2001) [Pubmed]
  45. Case report: electrophrenic respiration and discharge planning with a C1 quadriplegic. MacKechnie, J., Wade, P.A. Journal of neurosurgical nursing. (1984) [Pubmed]
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