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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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High rate of proV47A selection in HIV-2 patients failing lopinavir-based HAART.

We describe the emergence of the proV47A mutation in three out of five HIV-2-infected individuals failing lopinavir/ritonavir-based HAART. The appearance of such mutated variants resulted in high levels of phenotypic resistance to lopinavir, cross-resistance to indinavir, amprenavir, and hypersusceptibility to saquinavir. A search in HIV-2 databases revealed that proV47A is present in 8.6% of protease inhibitor (PI)-experienced patients but absent in all PI-naive patients. Its selection may be a common mutational pathway for developing resistance to lopinavir/ritonavir in HIV-2.[1]

References

  1. High rate of proV47A selection in HIV-2 patients failing lopinavir-based HAART. Rodés, B., Toro, C., Sheldon, J.A., Jiménez, V., Mansinho, K., Soriano, V. AIDS (2006) [Pubmed]
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