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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor.

Human NK cells and subsets of T cells or NKT cells express the orphan C-type lectin receptor CD161 (NKR-P1A) of unknown function. In contrast to rodents that possess several NKR-P1 genes coding for either activating or inhibitory receptors, the nature of signals delivered by the single human NKR-P1A receptor is still to be clarified. In this article, we show that the lectin-like transcript 1 (LLT1) molecule is a ligand for the CD161 receptor. Engagement of CD161 on NK cells with LLT1 expressed on target cells inhibited NK cell- mediated cytotoxicity and IFN-gamma secretion. Conversely, LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-gamma production by T cells. These findings identify a novel ligand/receptor pair that differentially regulate NK and T cell functions.[1]

References

  1. Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor. Aldemir, H., Prod'homme, V., Dumaurier, M.J., Retiere, C., Poupon, G., Cazareth, J., Bihl, F., Braud, V.M. J. Immunol. (2005) [Pubmed]
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