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Bannasch, D. et al.

D. Bannasch, C. Rinaldo, L. Millon, K. Latson, T. Spangler, S. Hubberty, L. Galuppo, L. Lowenstine,

SRY negative 64,XX intersex phenotype in an American saddlebred horse.

A female American saddlebred horse was presented for surgical correction of a possible pseudohermaphrodite condition. The horse had abnormal external genitalia and exhibited stallion-like behaviour. No evidence of uterine or ovarian tissue was identified on laparoscopic examination, but hypoplastic testicular-like tissue was removed, although this was found to contain no spermatogonia upon histopathological examination. A karyotype was performed and showed the normal chromosomal complement for a female horse (64,XX). Polymerase chain reaction to detect the SRY gene was negative in peripheral blood as well as the testicular-like tissue. This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.[1]

References

SRY negative 64,XX intersex phenotype in an American saddlebred horse. Bannasch, D., Rinaldo, C., Millon, L., Latson, K., Spangler, T., Hubberty, S., Galuppo, L., Lowenstine, L. Vet. J. (2007) [Pubmed]

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