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MeSH Review

Genes, sry

 
 
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Disease relevance of Genes, sry

 

High impact information on Genes, sry

  • Mammalian sex determination is governed by the presence of the sex determining region Y gene (SRY) on the Y chromosome [2].
  • We earlier described three lines of sex-reversed XY female mice deleted for sequences believed close to the testes-determining gene (Sry) on the Y chromosome short arm (Yp) [3].
  • The Y chromosome carries the sex-determining sex reversal Y (SRY) gene and recent studies show that it might also harbor genes that have important biological functions other than sex determination [4].
  • The possible control by androgens of gene expression of the two isozymes has been studied in brain tissues of animals exposed in utero to the androgen antagonist flutamide; the sex of the animals was determined by genetic sex screening of the SRY gene located on the Y-chromosome [5].
  • The reconstructed male lpr hepatocytes in the female wild-type mice were determined by a real-time quantitative PCR assay using the primers and probe for the sry gene [6].
 

Biological context of Genes, sry

 

Anatomical context of Genes, sry

 

Gene context of Genes, sry

 

Analytical, diagnostic and therapeutic context of Genes, sry

References

  1. The role of sexual related Y gene detection in the diagnosis of patients with gonadal dysgenesis. Yu, Q., Huang, S., Ye, L., Feng, L., He, F., Ye, J., Gu, C., Ge, Q. Chin. Med. J. (2001) [Pubmed]
  2. A 11.7-kb deletion triggers intersexuality and polledness in goats. Pailhoux, E., Vigier, B., Chaffaux, S., Servel, N., Taourit, S., Furet, J.P., Fellous, M., Grosclaude, F., Cribiu, E.P., Cotinot, C., Vaiman, D. Nat. Genet. (2001) [Pubmed]
  3. Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal. Laval, S.H., Glenister, P.H., Rasberry, C., Thornton, C.E., Mahadevaiah, S.K., Cooke, H.J., Burgoyne, P.S., Cattanach, B.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Y is there a risk to being male? Charchar, F.J., Tomaszewski, M., Strahorn, P., Champagne, B., Dominiczak, A.F. Trends Endocrinol. Metab. (2003) [Pubmed]
  5. Transient expression of the 5alpha-reductase type 2 isozyme in the rat brain in late fetal and early postnatal life. Poletti, A., Negri-Cesi, P., Rabuffetti, M., Colciago, A., Celotti, F., Martini, L. Endocrinology (1998) [Pubmed]
  6. Selective repopulation of mice liver after Fas-resistant hepatocyte transplantation. Fujino, M., Li, X.K., Kitazawa, Y., Funeshima, N., Guo, L., Okuyama, T., Amano, T., Amemiya, H., Suzuki, S. Cell transplantation. (2001) [Pubmed]
  7. Detection of sex-region Y (SRY) transcripts in human prostate adenocarcinoma and benign prostatic hypertrophy. Tricoli, J.V., Yao, J.L., D'Souza, S.A., Bracken, R.B. Genes Chromosomes Cancer (1993) [Pubmed]
  8. Sertoli-stromal cell tumor of the ovary: immunohistochemical, ultrastructural, and genetic studies. Kato, N., Fukase, M., Ono, I., Matsumoto, K., Okazaki, E., Motoyama, T. Hum. Pathol. (2001) [Pubmed]
  9. A de novo phe671eu mutation in the SRY gene in a patient with complete 46,XY gonadal dysgenesis. Zenteno, J.C., Carranza-Lira, S., Jiménez, A.L., Kofman, S. J. Endocrinol. Invest. (2003) [Pubmed]
  10. Report of an XX male with hypospadias and pubertal gynecomastia, SRY gene negative in blood leukocytes but SRY gene positive in testicular cells. Dardis, A., Saraco, N., Mendilaharzu, H., Rivarola, M., Belgorosky, A. Horm. Res. (1997) [Pubmed]
  11. Ovarian Sertoli-Leydig cell tumor: a SRY gene-independent pathway of pseudomale gonadal differentiation. Hittmair, A., Zelger, B.G., Obrist, P., Dirnhofer, S. Hum. Pathol. (1997) [Pubmed]
  12. Cloning and mutational analysis of SRY. Hawkins, J.R. Horm. Res. (1992) [Pubmed]
  13. Gender determination of the Linne's two-toed sloth (Choloepus didactylus) using SRY amplified from hair. Murata, K., Masuda, R. J. Vet. Med. Sci. (1996) [Pubmed]
  14. Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach. Su, H., Lau, Y.F. Am. J. Hum. Genet. (1993) [Pubmed]
  15. Hypertelorism and hypospadias associated with a de novo apparently balanced translocation between 8q22.3-23 and 20p13. Tar, A., Ion, A., Sólyom, J., Györvári, B., Stephenson, C., Barbaux, S., Nunes, M., Fellous, M., McElreavey, K. Am. J. Med. Genet. (1997) [Pubmed]
  16. Early transcription of the SRY gene by bovine preimplantation embryos. Gutiérrez-Adán, A., Behboodi, E., Murray, J.D., Anderson, G.B. Mol. Reprod. Dev. (1997) [Pubmed]
  17. The SRY gene HMG-box in micro- and megabats. Bullejos, M., Sánchez, A., Burgos, M., Jiménez, R., Díaz De La Guardia, R. Cytogenet. Cell Genet. (2000) [Pubmed]
  18. Evaluation of the clinical usefulness of isolation of fetal DNA from the maternal circulation. Siva, S.C., Johnson, S.I., McCracken, S.A., Morris, J.M. The Australian & New Zealand journal of obstetrics & gynaecology. (2003) [Pubmed]
  19. Migration of intravenously grafted mesenchymal stem cells to injured heart in rats. Jiang, W.H., Ma, A.Q., Zhang, Y.M., Han, K., Liu, Y., Zhang, Z.T., Wang, T.Z., Huang, X., Zheng, X.P. Sheng li xue bao [Acta physiologica Sinica]. (2005) [Pubmed]
 
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