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Disease relevance of Spermatogonia


High impact information on Spermatogonia


Chemical compound and disease context of Spermatogonia


Biological context of Spermatogonia


Anatomical context of Spermatogonia


Associations of Spermatogonia with chemical compounds


Gene context of Spermatogonia


Analytical, diagnostic and therapeutic context of Spermatogonia


  1. HIV-1 nucleic acids localize to the spermatogonia and their progeny. A study by polymerase chain reaction in situ hybridization. Nuovo, G.J., Becker, J., Simsir, A., Margiotta, M., Khalife, G., Shevchuk, M. Am. J. Pathol. (1994) [Pubmed]
  2. SPOC1, a novel PHD-finger protein: association with residual disease and survival in ovarian cancer. Mohrmann, G., Hengstler, J.G., Hofmann, T.G., Endele, S.U., Lee, B., Stelzer, C., Zabel, B., Brieger, J., Hasenclever, D., Tanner, B., Sagemueller, J., Sehouli, J., Will, H., Winterpacht, A. Int. J. Cancer (2005) [Pubmed]
  3. Antimutagenic properties of WR 2721 and of a radioprotective mixture, ATP-AET-serotonin, with regard to X ray induced reciprocal translocations in mouse spermatogonia. Benova, D. Int. J. Radiat. Oncol. Biol. Phys. (1987) [Pubmed]
  4. The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. Satie, A.P., Rajpert-De Meyts, E., Spagnoli, G.C., Henno, S., Olivo, L., Jacobsen, G.K., Rioux-Leclercq, N., Jégou, B., Samson, M. Lab. Invest. (2002) [Pubmed]
  5. Further evidence for the aneuploidogenic properties of chelating agents: induction of micronuclei in mouse male germ cells by EDTA. Russo, A., Levis, A.G. Environ. Mol. Mutagen. (1992) [Pubmed]
  6. Essential role of Plzf in maintenance of spermatogonial stem cells. Costoya, J.A., Hobbs, R.M., Barna, M., Cattoretti, G., Manova, K., Sukhwani, M., Orwig, K.E., Wolgemuth, D.J., Pandolfi, P.P. Nat. Genet. (2004) [Pubmed]
  7. Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Takeuchi, A., Mishina, Y., Miyaishi, O., Kojima, E., Hasegawa, T., Isobe, K. Nat. Genet. (2003) [Pubmed]
  8. The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Akhmanova, A., Mausset-Bonnefont, A.L., van Cappellen, W., Keijzer, N., Hoogenraad, C.C., Stepanova, T., Drabek, K., van der Wees, J., Mommaas, M., Onderwater, J., van der Meulen, H., Tanenbaum, M.E., Medema, R.H., Hoogerbrugge, J., Vreeburg, J., Uringa, E.J., Grootegoed, J.A., Grosveld, F., Galjart, N. Genes Dev. (2005) [Pubmed]
  9. Expression of DAZ, an azoospermia factor candidate, in human spermatogonia. Menke, D.B., Mutter, G.L., Page, D.C. Am. J. Hum. Genet. (1997) [Pubmed]
  10. The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle. Scherf, U., Pastan, I., Willingham, M.C., Brinkmann, U. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  11. Restoration of spermatogenesis in dibromochloropropane (DBCP)-treated rats by hormone suppression. Meistrich, M.L., Wilson, G., Porter, K.L., Huhtaniemi, I., Shetty, G., Shuttlesworth, G.A. Toxicol. Sci. (2003) [Pubmed]
  12. Further experience of the mouse dominant cataract mutation test from an experiment with ethylnitrosourea. West, J.D., Fisher, G. Mutat. Res. (1986) [Pubmed]
  13. Hormonal protection from cyclophosphamide-induced inactivation of rat stem spermatogonia. Meistrich, M.L., Parchuri, N., Wilson, G., Kurdoglu, B., Kangasniemi, M. J. Androl. (1995) [Pubmed]
  14. Induction of sister-chromatid exchanges by chemotherapeutic drugs in spermatogonia of mice: effects of procarbazine, adriamycin, cyclophosphamide and mitomycin C. Abraham, S.K., Fränz, J. Mutat. Res. (1983) [Pubmed]
  15. Clastogenic effects of acrylamide in mouse bone marrow cells. Adler, I.D., Ingwersen, I., Kliesch, U., el Tarras, A. Mutat. Res. (1988) [Pubmed]
  16. The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Migeon, B.R., Luo, S., Jani, M., Jeppesen, P. Am. J. Hum. Genet. (1994) [Pubmed]
  17. Viability of rat spermatogenic cells in vitro is facilitated by their coculture with Sertoli cells in serum-free hormone-supplemented medium. Tres, L.L., Kierszenbaum, A.L. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  18. Hormonal induction of all stages of spermatogenesis in vitro in the male Japanese eel (Anguilla japonica). Miura, T., Yamauchi, K., Takahashi, H., Nagahama, Y. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  19. Enhanced expression of the murine FMR1 gene during germ cell proliferation suggests a special function in both the male and the female gonad. Bächner, D., Manca, A., Steinbach, P., Wöhrle, D., Just, W., Vogel, W., Hameister, H., Poustka, A. Hum. Mol. Genet. (1993) [Pubmed]
  20. Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene. Brown, G.M., Furlong, R.A., Sargent, C.A., Erickson, R.P., Longepied, G., Mitchell, M., Jones, M.H., Hargreave, T.B., Cooke, H.J., Affara, N.A. Hum. Mol. Genet. (1998) [Pubmed]
  21. Immunochemical detection of metallothionein in specific epithelial cells of rat organs. Danielson, K.G., Ohi, S., Huang, P.C. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  22. Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse. Rinchik, E.M., Bangham, J.W., Hunsicker, P.R., Cacheiro, N.L., Kwon, B.S., Jackson, I.J., Russell, L.B. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  23. Instability of the CGG repeat and expression of the FMR1 protein in a male fragile X patient with a lung tumor. de Graaff, E., Willemsen, R., Zhong, N., de Die-Smulders, C.E., Brown, W.T., Freling, G., Oostra, B. Am. J. Hum. Genet. (1995) [Pubmed]
  24. Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1. Coy, J.F., Sedlacek, Z., Bächner, D., Hameister, H., Joos, S., Lichter, P., Delius, H., Poustka, A. Hum. Mol. Genet. (1995) [Pubmed]
  25. Effects of spaceflight on the spermatogonial population of rat seminiferous epithelium. Sapp, W.J., Philpott, D.E., Williams, C.S., Kato, K., Stevenson, J., Vasquez, M., Serova, L.V. FASEB J. (1990) [Pubmed]
  26. Dose--response curve for ethylnitrosourea-induced specific-locus mutations in mouse spermatogonia. Russell, W.L., Hunsicker, P.R., Raymer, G.D., Steele, M.H., Stelzner, K.F., Thompson, H.M. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  27. Protection from procarbazine-induced testicular damage by hormonal pretreatment does not involve arrest of spermatogonial proliferation. Meistrich, M.L., Wilson, G., Zhang, Y., Kurdoglu, B., Terry, N.H. Cancer Res. (1997) [Pubmed]
  28. Testicular xenografts: a novel approach to study cytotoxic damage in juvenile primate testis. Jahnukainen, K., Ehmcke, J., Schlatt, S. Cancer Res. (2006) [Pubmed]
  29. Cytotoxic effects of chemotherapeutic drugs on mouse testis cells. Lu, C.C., Meistrich, M.L. Cancer Res. (1979) [Pubmed]
  30. Hormonal protection from procarbazine-induced testicular damage is selective for survival and recovery of stem spermatogonia. Meistrich, M.L., Wilson, G., Ye, W.S., Kurdoglu, B., Parchuri, N., Terry, N.H. Cancer Res. (1994) [Pubmed]
  31. The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region. Mazeyrat, S., Saut, N., Sargent, C.A., Grimmond, S., Longepied, G., Ehrmann, I.E., Ellis, P.S., Greenfield, A., Affara, N.A., Mitchell, M.J. Hum. Mol. Genet. (1998) [Pubmed]
  32. Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCF. Ohta, H., Yomogida, K., Dohmae, K., Nishimune, Y. Development (2000) [Pubmed]
  33. Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia. Feng, L.X., Ravindranath, N., Dym, M. J. Biol. Chem. (2000) [Pubmed]
  34. The GDNF/RET signaling pathway and human diseases. Takahashi, M. Cytokine Growth Factor Rev. (2001) [Pubmed]
  35. G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. Sallese, M., Mariggiò, S., Collodel, G., Moretti, E., Piomboni, P., Baccetti, B., De Blasi, A. J. Biol. Chem. (1997) [Pubmed]
  36. Effect of dose fractionation on the ethylnitrosourea induction of specific-locus mutations in mouse spermatogonia. Russell, W.L., Hunsicker, P.R., Carpenter, D.A., Cornett, C.V., Guinn, G.M. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  37. Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase. Freeman, J.W., Busch, R.K., Gyorkey, F., Gyorkey, P., Ross, B.E., Busch, H. Cancer Res. (1988) [Pubmed]
  38. Insulin-like growth factors selectively stimulate spermatogonial, but not meiotic, deoxyribonucleic acid synthesis during rat spermatogenesis. Söder, O., Bang, P., Wahab, A., Parvinen, M. Endocrinology (1992) [Pubmed]
  39. Characteristics of A spermatogonia and preleptotene spermatocytes in the vitamin A-deficient rat testis. van Pelt, A.M., van Dissel-Emiliani, F.M., Gaemers, I.C., van der Burg, M.J., Tanke, H.J., de Rooij, D.G. Biol. Reprod. (1995) [Pubmed]
  40. Insulin-like growth factor-II/cation-independent mannose 6-phosphate receptor mediates paracrine interactions during spermatogonial development. Tsuruta, J.K., Eddy, E.M., O'Brien, D.A. Biol. Reprod. (2000) [Pubmed]
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