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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Repetitive nerve stimulation of facial muscles in MuSK antibody-positive myasthenia gravis.

To better define electrophysiological abnormalities in myasthenia gravis (MG) patients with muscle-specific tyrosine kinase (MuSK) antibodies (Ab), we compared electrophysiological features of 14 MuSK Ab-positive, 73 acetylcholine receptor antibody (AChR Ab)-positive, and 22 MuSK and AChR Ab-negative (seronegative) patients with generalized disease. Repetitive nerve stimulation (RNS) abnormalities were observed in 86% of MuSK Ab-positive and 82% of AChR Ab-positive patients but in only 55% of seronegative patients. RNS decrements in the orbicularis oculi were more common and severe in the MuSK Ab-positive patients than the other two groups. Single-fiber electromyography (SFEMG) of the extensor digitorum communis was abnormal in 90% of MuSK Ab-positive patients. The high frequency of RNS abnormalities in facial muscles in the MuSK Ab-positive population reflects the propensity for facial muscle involvement in this form of MG and emphasizes the importance of including facial muscles in RNS protocols when evaluating these patients.[1]


  1. Repetitive nerve stimulation of facial muscles in MuSK antibody-positive myasthenia gravis. Oh, S.J., Hatanaka, Y., Hemmi, S., Young, A.M., Scheufele, M.L., Nations, S.P., Lu, L., Claussen, G.C., Wolfe, G.I. Muscle Nerve (2006) [Pubmed]
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