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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Induction of neurite outgrowth by (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol from PC12 cells.

A lignan derivative, (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol (DHDA), was isolated from Kalopanax septemlobus L. and was observed to have neuritogenic activity. DHDA at 50 microM caused a marked induction of neurite outgrowth and an enhancement of nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. However, it did not exhibit any neurotrophic action. At 50 microM, DHDA enhanced NGF-induced neurite-bearing activity. This activity was partially blocked by the mitogen-activated protein kinase ( MAPK) inhibitor PD98059 and by GF109203X, a protein kinase C ( PKC) inhibitor. These results suggest that DHDA can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.[1]


  1. Induction of neurite outgrowth by (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol from PC12 cells. Shin, J.S., Kim, Y.M., Hong, S.S., Kang, H.S., Yang, Y.J., Lee, D.K., Hwang, B.Y., Ro, J.S., Lee, M.K. Arch. Pharm. Res. (2005) [Pubmed]
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