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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.

Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC(50) values in the micromolar range.[1]

References

  1. Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Huang, W., Li, J., Zhang, W., Zhou, Y., Xie, C., Luo, Y., Li, Y., Wang, J., Li, J., Lu, W. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
 
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