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Chemical Compound Review

Miltiron     8,8-dimethyl-2-propan-2-yl- 6,7-dihydro-5H...

Synonyms: Miltirone, Rosmariquinone, CHEMBL45830, AG-K-03646, SureCN13568178, ...
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Psychiatry related information on C13715

  • Pure miltirone reduced alcohol intake in alcohol-experienced rats and delayed acquisition of alcohol-drinking behavior in alcohol-naive rats [1].

High impact information on C13715

  • Finally, linking ring A and B with a -CH2CH2- bridge results in analogue 89, which is 6 times more potent than miltirone at the central benzodiazepine receptor (IC50 = 0.05 microM) [2].
  • On the basis of their inhibition of [3H]flunitrazepam binding to bovine cerebral cortex membranes, it is apparent that ring A of miltirone is essential for affinity [2].
  • Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases [3].


  1. Identification of Miltirone as Active Ingredient of Salvia miltiorrhiza Responsible for the Reducing Effect of Root Extracts on Alcohol Intake in Rats. Colombo, G., Serra, S., Vacca, G., Orrù, A., Maccioni, P., Morazzoni, P., Bombardelli, E., Riva, A., Gessa, G.L., Carai, M.A. Alcohol. Clin. Exp. Res. (2006) [Pubmed]
  2. Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen). Chang, H.M., Chui, K.Y., Tan, F.W., Yang, Y., Zhong, Z.P., Lee, C.M., Sham, H.L., Wong, H.N. J. Med. Chem. (1991) [Pubmed]
  3. Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Huang, W., Li, J., Zhang, W., Zhou, Y., Xie, C., Luo, Y., Li, Y., Wang, J., Li, J., Lu, W. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
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