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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Synthesis and ocular effects of imidazole nitrolic acid and amidoxime esters.

Esters of 1-(H)-imidazole-5-nitrolic acid and 1-methyl-imidazole-5-carboxamide oxime were prepared to study the effect of esterification on the ocular effects of these compounds. Esterifications were performed with acid chloride. Acid chloride also reacts with the ring nitrogen of 1-(H)-imidazole-5-nitrolic acid, but the desired esters could be selectively prepared by adjustment of the reaction conditions. Esterification led to loss of the ocular effects exhibited by the parent compounds.[1]


  1. Synthesis and ocular effects of imidazole nitrolic acid and amidoxime esters. Oresmaa, L., Kotikoski, H., Haukka, M., Oksala, O., Pohjala, E., Vapaatalo, H., Vainiotalo, P., Aulaskari, P. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
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