Disease relevance of BRN 0752190

• Bacillus subtilis spores were killed by CuCl(2)-ascorbic acid, chloride ions were essential for killing of spores, and spores with defective coats were killed more rapidly [1].
• Accumulation and toxicity of inorganic arsenic forms As(III) and As(V) to the green microalga Stichococcus bacillaris depended on environmental variables. pH of exposure and to a lesser extent elevated concentrations of humic acid, chloride and orthophosphate ions affected arsenic accumulation and its toxicity [2].

High impact information on BRN 0752190

• Vagotomy uncompetitively (ED50 increase, Vmax decrease) inhibited the pentagastrin dose response of acid, chloride, and pepsin output [3].
• Substituted acrylamides were prepared by direct acylation of the corresponding 6-amines with the requisite acid or acid chloride [4].
• Separation of the methyl esters of the four isomers of 2-hydroxy-3-methylhexadecanoic acid was achieved by gas chromatography after derivatization of the hydroxy group with R-2-methoxy-2-trifluoromethylphenylacetic acid chloride and the absolute configuration of the four isomers was determined [5].
• Base hydrolysis of 1b gave the acid 10 which, via its acid chloride and subsequent treatment with the appropriate amine, formed the target compounds 2a-h. The pharmacological profile indicated that the cyano analogues 1a-e had very high CB1 binding affinity (0.36-13 nM) and high in vivo potency as agonists [6].
• 8-Methoxy- and 8-methylquinazolinones (14-34) were readily prepared by acylation of 3-substituted anthranilamides with the appropriate acid chloride, followed by base-catalyzed cyclization [7].

Chemical compound and disease context of BRN 0752190

• The prodrugs (glyceride derivatives) 3a and 3b of diclofenac were prepared by reacting 1, 2, 3-trihydroxy propane-1,3-dipalmitate/stearate with the acid chloride of diclofenac as potential prodrugs to reduce the gastrointestinal toxicity associated with them [8].

Biological context of BRN 0752190

• METHODS: The procedure involved the instantaneous hydrolysis of [1-11C]acetyl chloride back to [1-11C]acetic acid by simply trapping the volatile acid chloride in physiological saline [9].
• Thus, covalent binding to subcellular proteins by the trifluoroacetyl acid chloride intermediate generated by oxidative halothane biotransformation is implicated as a mechanism of centrilobular necrosis in guinea pigs [10].
• Acylation of 19 with acid chloride 31d, followed by hydrolysis of the tert-butyl ester and decarboxylation with 9:1 CH2Cl2/TFA and very mild basic hydrolysis of the methoxyacetate ester, afforded jenamidines A1/A2 (3) in 45% yield [11].
• Esterifications were performed with acid chloride [12].

Anatomical context of BRN 0752190

• Thin polymeric membranes have been formed by liquid/liquid interfacial copolymerization of a sterically demanding tetraphenylporphyrin derivative having reactive phenol substituents and a second porphyrin having reactive acid chloride groups [13].

Associations of BRN 0752190 with other chemical compounds

• METHODS: The 3(R)-(+)-BMIPP analog was synthesized by initial acylation of a thiophene template with the acid chloride of ethyl 3(R)-methylglutarate [14].
• (4Z)-9-(5-Carboxypentyl)-2,3,7,8-tetramethyl-(10H)-dipyrrin- 1-one (1, semirubin), a new dipyrrinone model for one-half of bilirubin, the yellow-orange neurotoxic pigment of jaundice, was synthesized following Friedel-Crafts acylation of 2,3,7, 8-tetramethyl-(10H)-dipyrrin-1-one (5) with the half-ester acid chloride of adipic acid [15].
• Simultaneous determination of the acid chloride S-benzoyl-3-mercapto-2-methylpropanoyl chloride and residual carboxylic acid by capillary gas chromatography [16].
• On the other hand, the acylation of the two 17 beta-tetrahydropyranyloxy-5-en-7-amines with the acid chloride of terephthalic acid monomethyl ester led to the more rigid 7 beta- and 7 alpha-terephthalamido methyl ester side-chains [17].
• Homologs of melatonin were prepared by acylation of 5-methoxytryptamine with the appropriate acid chloride or anhydride [18].

Gene context of BRN 0752190

• Acylation of 26 with acid chloride 38d gave 39d, which was deprotected with TFA and then mild base to give 8 in 45% yield from 26 [19].
• A new procedure for the preparation of unsymmetrical diacyl dipyrromethanes has been developed that involves (1) monoacylation with EtMgBr and a pyridyl benzothioate followed by (2) introduction of the second acyl unit upon reaction with EtMgBr and an acid chloride [20].

Analytical, diagnostic and therapeutic context of BRN 0752190

• The separation by crystallization of the pair of cryptophane diastereomers 1 a and 1 b, obtained in 1:1 ratio by treating racemic anti cryptophanol-A (2) with (-)-camphanic acid chloride, provided a substantial amount of optically pure material (diastereomeric excess>98 %) [21].
• The determination is more selective than the usual titration methods, which do not differentiate among acids with similar pK's. Relative standard deviations of the acid chloride determination are 1.0-2.5% [22].
• The covalent immobilization of alpha-amylase on new isocyanate, acid chloride and carboxylic acid--activated plastic supports shows the viability of such supports for immobilizing enzymes, especially those reacting with 1,6-diaminohexane and glutaraldehyde for producing side arms [23].

References