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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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 Xiang,  
 

A +TIP for a smooth trip.

Is there a cellular mechanism for preventing a depolymerizing microtubule track from "slipping out from under" its cargo? A recent study in budding yeast indicates that when a chromosome is transported to the minus end of a spindle microtubule, its kinetochore-bound microtubule plus end-tracking protein (+TIP) Stu2 may move to the plus end to promote rescue; i.e., to switch the depolymerizing end to a polymerizing end. The possibility that other +TIPs may play a similar role in sustaining a microtubule track during vesicular transport deserves investigation.[1]

References

  1. A +TIP for a smooth trip. Xiang, X. J. Cell Biol. (2006) [Pubmed]
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