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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action.

The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase- mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular Cell paper that transient JNK activation suppresses TNF-alpha-induced cell death.[1]

References

  1. A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action. Lin, A. Dev. Cell (2006) [Pubmed]
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