High impact information on Time Factors

• A similar time factor was involved when cells were treated with a combination of cis-DDP and ara-C before their exposure to thiourea, but in this case thiourea was only able to prevent completely the cytotoxic effect when added simultaneously with the drug combination [1].
• Relative retention time factors for several functional groups encountered in sterol intermediates in cholesterol biosynthesis have been determined for both reverse-phase and silicic acid HPLC systems [2].
• RESULTS: The mechanical factor time of intermittence significantly altered the synthesis and release of fibronectin by cartilage explants, whereas the tested range of load magnitudes, as well as the duration of loading, seemed to be of subordinate importance [3].
• Using combined T2 and T3 data, the increase in dose required to maintain a constant local control (the time factor) was between 0.5 and 0.6 Gy per day [4].
• The time factor is found not to be significant by the NSD-model for the treatment times used (less than or equal to 68 days) at the 95% level of confidence [5].

Biological context of Time Factors

• The role of the time factor, ie, of signaling kinetics, as a determinant of selectivity is discussed with emphasis on the receptor tyrosine kinases and cytokine receptors, and especially mitogenic versus metabolic signaling by insulin and insulin-like growth factor-I (IGF-I) [6].
• These findings suggest that variations in the amount of platelet aggregation observed with epinephrine may be a reflection of differences in the time factor involved in testing [7].

Associations of Time Factors with chemical compounds

• In regard to the time factor, the conspicuous drop in the occurrence of the Pg7 fraction corresponds to the new qualitative relationship between the pepsinogen activity in the urine and the creatinine concentration in the urine and between the former and the urine osmolality [8].
• However the effect of caffeine was dependent on the time factor as well as on the dose [9].
• New evidence on benzodiazepine use and falls: the time factor [10].
• Notion of time factor in calcium absorption. Influence of sex, intestinal site and L-xylose in the mature rat [11].
• The time factor was critical for the effects observed, and the results supported the view that estrogen may alter behavior mediated by dopaminergic pathways [12].

Gene context of Time Factors

• A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action [13].
• Moreover, the time factor in ECP measurement is an important variable because ECP levels differ in chronic stable asthma, during acute exacerbations of asthma, and after allergen challenge [14].
• Activation energies Ea characterizing the motions were 6.1 +/- 0.5 and 11.9 +/- 0.9 kJ/mol; the pre-exponential time factors tau 0 were (2.3 +/- 0.1) x 10(-13) and (2.85 +/- 0.2) x 10(-13) s, respectively [15].
• Role of the time factor in signaling specificity: application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases [6].
• Statistical analysis (ANOVA) showed "the time factor" was statistically significant [16].

References