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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system.

A number of viral and eukaryotic proteins which undergo a lipophilic modification by the enzyme N-myristoyltransferase (NMT: NMT1 and NMT2) are required for signal transduction and regulatory functions. To investigate whether NMT2 contributes to the pathogenesis of colorectal carcinoma, we observed a higher expression of NMT2 in most of the cases of cancerous tissues compared to normal tissues (84.6% of cases; P < 0.05) by Western blot analysis. Furthermore, protein-protein interaction of NMTs revealed that m-calpain interacts with NMT1 while caspase-3 interacts with NMT2. Our findings provide the first evidence of higher expression of NMT2 in human colorectal adenocarcinomas and the interaction of both forms of NMT with various signaling molecules.[1]

References

  1. N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system. Selvakumar, P., Smith-Windsor, E., Bonham, K., Sharma, R.K. FEBS Lett. (2006) [Pubmed]
 
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