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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation.

Phytol is a naturally occurring precursor of phytanic acid. The last step in the conversion of phytol to phytanoyl-CoA is the reduction of phytenoyl-CoA mediated by an, as yet, unidentified enzyme. A candidate for this reaction is a previously described peroxisomal trans-2-enoyl-CoA reductase ( TER). To investigate this, human TER was expressed in E. coli as an MBP-fusion protein. The purified recombinant protein was shown to have high reductase activity towards trans-phytenoyl-CoA, but not towards the peroxisomal beta-oxidation intermediates C24:1-CoA and pristenoyl-CoA. In conclusion, our results show that human TER is responsible for the reduction of phytenoyl-CoA to phytanoyl-CoA in peroxisomes.[1]


  1. Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation. Gloerich, J., Ruiter, J.P., van den Brink, D.M., Ofman, R., Ferdinandusse, S., Wanders, R.J. FEBS Lett. (2006) [Pubmed]
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