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Gene Review

PECR  -  peroxisomal trans-2-enoyl-CoA reductase

Homo sapiens

Synonyms: 2,4-dienoyl-CoA reductase-related protein, DCR-RP, DCRRP, HPDHASE, HPDHase, ...
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High impact information on PECR

  • At low concentrations, TERP stimulates ERalpha transcriptional activity in transient transfection assays [1].
  • A dimerization mutant of TERP, TERP L509R, stimulated ERalpha transcription at all concentrations [1].
  • These results indicate that we have sequenced the complete terp operon [2].
  • Mutation of ERE1 site completely abolishes the estradiol-dependent transcription, indicating that ERE1 site is sufficient to confer estrogen responsiveness to TERP promoter [3].
  • EMSAs showed that a single Pit-1 DNA binding element in the vicinity of the TATA box is sufficient to confer response by the TERP promoter [3].

Anatomical context of PECR

  • TERP promoter constructs were highly active in MMQ cells, a pure lactotrope cell line, whereas a low basal activity was detected in alphaT3-1 gonadotrope cells or in COS-7 monkey kidney cells [3].

Associations of PECR with chemical compounds


Analytical, diagnostic and therapeutic context of PECR

  • CONCLUSIONS: Prolonged intra- and extraperitoneal CO2 insufflation for TERP resulted in significant, but mostly clinically unimportant, hemodynamic alterations [5].
  • METHODS: For this study, 20 patients were assigned to receive totally endoscopic robot-assisted radical prostatectomy (TERP) via the intra- or extraperitoneal approach [5].
  • Thirty-nine patients who were admitted to a midwestern hospital with a coronary problem and who were candidates for cardiac rehabilitation completed the Patient Entrance Into a Cardiac Rehabilitation Program (PECRP) questionnaire [6].


  1. Truncated estrogen receptor product-1 stimulates estrogen receptor alpha transcriptional activity by titration of repressor proteins. Lin, V.Y., Resnick, E.M., Shupnik, M.A. J. Biol. Chem. (2003) [Pubmed]
  2. Cytochrome P-450terp. Isolation and purification of the protein and cloning and sequencing of its operon. Peterson, J.A., Lu, J.Y., Geisselsoder, J., Graham-Lorence, S., Carmona, C., Witney, F., Lorence, M.C. J. Biol. Chem. (1992) [Pubmed]
  3. Regulation of the intronic promoter of rat estrogen receptor alpha gene, responsible for truncated estrogen receptor product-1 expression. Schausi, D., Tiffoche, C., Thieulant, M.L. Endocrinology (2003) [Pubmed]
  4. Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation. Gloerich, J., Ruiter, J.P., van den Brink, D.M., Ofman, R., Ferdinandusse, S., Wanders, R.J. FEBS Lett. (2006) [Pubmed]
  5. Prolonged intraperitoneal versus extraperitoneal insufflation of carbon dioxide in patients undergoing totally endoscopic robot-assisted radical prostatectomy. Meininger, D., Byhahn, C., Wolfram, M., Mierdl, S., Kessler, P., Westphal, K. Surgical endoscopy. (2004) [Pubmed]
  6. Factors influencing patient entrance into a cardiac rehabilitation program. Hiatt, A.M., Hoenshell-Nelson, N., Zimmerman, L. Cardio-vascular nursing. (1990) [Pubmed]
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