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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Adsorption and mineralization effects of citrate and phosphocitrate on hydroxyapatite.

The adsorption of citrate and phosphocitrate ions by hydroxyapatite (HAP) surfaces and their influence on the constant composition growth kinetics of HAP have been investigated. Phosphocitrate was strongly adsorbed to HAP and inhibited crystal growth. When HAP surfaces containing preadsorbed citrate were exposed to phosphocitrate, the uptake of the latter markedly increased. The two additives behaved synergistically in their HAP crystal growth inhibition.[1]


  1. Adsorption and mineralization effects of citrate and phosphocitrate on hydroxyapatite. Johnsson, M., Richardson, C.F., Sallis, J.D., Nancollas, G.H. Calcif. Tissue Int. (1991) [Pubmed]
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