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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Novel bioactive dammarane caffeoyl esters from Celastrus rosthornianus.

Three new dammar-type triterpenoid caffeates (1-3) were isolated from the stalks of Celastrus rosthornianus Loes. Their structures were established through various spectral studies as 3beta,20(S),24(S)-trihydroxyldammar-25-ene 3-caffeate (1), 3beta,20(S),24(R)-trihydroxyldammar-25-ene 3-caffeate (2) and 3beta,20(S),25-trihydroxyldammar-23(Z)-ene 3-caffeate (3), respectively. The three new compounds (1-3) showed strong antitumor activity against the human cervical squamous carcinoma cell line with IC (50) values of 6.4, 5.3 and 6.5 microg/mL, respectively. The biological analyses of 1-3 and their hydrolysates 1a-3a indicated that the caffeoyl group could increase the bioactivity.[1]

References

  1. Novel bioactive dammarane caffeoyl esters from Celastrus rosthornianus. Wang, K.W., Sun, C.R., Wu, X.D., Pan, Y.J. Planta Med. (2006) [Pubmed]
 
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