Membrane transport of hydrogen peroxide.
Hydrogen peroxide (H(2)O(2)) belongs to the reactive oxygen species (ROS), known as oxidants that can react with various cellular targets thereby causing cell damage or even cell death. On the other hand, recent work has demonstrated that H(2)O(2) also functions as a signalling molecule controlling different essential processes in plants and mammals. Because of these opposing functions the cellular level of H(2)O(2) is likely to be subjected to tight regulation via processes involved in production, distribution and removal. Substantial progress has been made exploring the formation and scavenging of H(2)O(2), whereas little is known about how this signal molecule is transported from its site of origin to the place of action or detoxification. From work in yeast and bacteria it is clear that the diffusion of H(2)O(2) across membranes is limited. We have now obtained direct evidence that selected aquaporin homologues from plants and mammals have the capacity to channel H(2)O(2) across membranes. The main focus of this review is (i) to summarize the most recent evidence for a signalling role of H(2)O(2) in various pathways in plants and mammals and (ii) to discuss the relevance of specific transport of H(2)O(2).[1]References
- Membrane transport of hydrogen peroxide. Bienert, G.P., Schjoerring, J.K., Jahn, T.P. Biochim. Biophys. Acta (2006) [Pubmed]
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