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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Okadaic acid inhibits activation of K-Cl cotransport in red blood cells containing hemoglobins S and C.

The sensitivity of red blood cells containing hemoglobins S and C to activation of K-Cl cotransport by osmotic swelling and acidification was reduced by okadaic acid, a specific protein phosphatase inhibitor. The dose-response curve for okadaic acid suggests its action is on a type 1 protein phosphatase. Okadaic acid has been previously shown to inhibit swelling-induced activation of K-Cl cotransport in red blood cells from rabbits, normal humans, and dogs. The present work confirms the observation that okadaic acid blunts the stimulation of K-Cl cotransport by cell swelling. The new information is that okadaic acid reduces the effects of hemoglobins S and C on the volume and pH sensitivity of K-Cl cotransport. Thus the influences of cell volume, pH, and mutant hemoglobins may all be mediated via a common mechanisms that affects the phosphorylation state, either of the K-Cl. cotransporter itself or of a protein that regulates its function.[1]

References

  1. Okadaic acid inhibits activation of K-Cl cotransport in red blood cells containing hemoglobins S and C. Orringer, E.P., Brockenbrough, J.S., Whitney, J.A., Glosson, P.S., Parker, J.C. Am. J. Physiol. (1991) [Pubmed]
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