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Gene Review

PPP1R1A  -  protein phosphatase 1, regulatory...

Homo sapiens

Synonyms: I-1, I1, IPP-1, IPP1, Protein phosphatase 1 regulatory subunit 1A, ...
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Disease relevance of PPP1R1A


Psychiatry related information on PPP1R1A


High impact information on PPP1R1A


Chemical compound and disease context of PPP1R1A


Biological context of PPP1R1A


Anatomical context of PPP1R1A


Associations of PPP1R1A with chemical compounds


Regulatory relationships of PPP1R1A


Other interactions of PPP1R1A


Analytical, diagnostic and therapeutic context of PPP1R1A

  • A similar cell-specific apoptosis induction was also observed after treatment with dinophysistoxin-1 (an active OA analogue) and with calyculin A (a structurally unrelated protein phosphatase inhibitor) but not with analogues that either are inactive or penetrate epithelial cells poorly [38].
  • We have isolated three major cDNA fragments of protein phosphatase inhibitor-1 from human brain and liver by RT-PCR [39].
  • Biotyping and serotyping of 13 German isolates of S. faecalis of phage type I1 from four clinical sources and tripartite typing of three control strains provided additional evidence for the potential of biotyping in distinguishing between strains of identical serotype and phage type [40].
  • At certain tapping forces, I-1 was of significantly lower amplitude and longer duration in the arthritis group than in the control group, but latency and threshold did not differ [41].


  1. Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. Endo, S., Zhou, X., Connor, J., Wang, B., Shenolikar, S. Biochemistry (1996) [Pubmed]
  2. Okadaic acid, a protein phosphatase inhibitor, blocks calcium changes, gene expression, and cell death induced by gibberellin in wheat aleurone cells. Kuo, A., Cappelluti, S., Cervantes-Cervantes, M., Rodriguez, M., Bush, D.S. Plant Cell (1996) [Pubmed]
  3. Ceramide accumulation precedes caspase-dependent apoptosis in CHP-100 neuroepithelioma cells exposed to the protein phosphatase inhibitor okadaic acid. Spinedi, A., Di Bartolomeo, S., Di Sano, F., Rodolfo, C., Ambrosino, A., Piacentini, M. Cell Death Differ. (1999) [Pubmed]
  4. Phlebotomus papatasi saliva inhibits protein phosphatase activity and nitric oxide production by murine macrophages. Waitumbi, J., Warburg, A. Infect. Immun. (1998) [Pubmed]
  5. Increased production of paired helical filament epitopes in a cell culture system reduces the turnover of tau. Vincent, I., Rosado, M., Kim, E., Davies, P. J. Neurochem. (1994) [Pubmed]
  6. Calcium/calmodulin-dependent protein kinase II in squid synaptosomes. Bass, M., Pant, H.C., Gainer, H., Soderling, T.R. J. Neurochem. (1987) [Pubmed]
  7. Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP. Han, J., Han, L., Tiwari, P., Wen, Z., Zheng, J.Q. J. Cell Biol. (2007) [Pubmed]
  8. Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. Goodarzi, A.A., Jonnalagadda, J.C., Douglas, P., Young, D., Ye, R., Moorhead, G.B., Lees-Miller, S.P., Khanna, K.K. EMBO J. (2004) [Pubmed]
  9. Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells. Endo, S., Suzuki, M., Sumi, M., Nairn, A.C., Morita, R., Yamakawa, K., Greengard, P., Ito, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  10. The protein phosphatase inhibitor calyculin A mimics elicitor action in plant cells and induces rapid hyperphosphorylation of specific proteins as revealed by pulse labeling with [33P]phosphate. Felix, G., Regenass, M., Spanu, P., Boller, T. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  11. Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers. Bezrookove, V., Smits, R., Moeslein, G., Fodde, R., Tanke, H.J., Raap, A.K., Darroudi, F. Genes Chromosomes Cancer (2003) [Pubmed]
  12. Capnocytophaga gingivalis: effects of glucose concentration on growth and hydrolytic enzyme production. Spratt, D.A., Greenman, J., Schaffer, A.G. Microbiology (Reading, Engl.) (1996) [Pubmed]
  13. Morphological changes and reorganization of actinfilaments in human myeloid leukemia cells induced by a novel protein phosphatase inhibitor, tautomycin. Kurisaki, T., Magae, J., Nagai, K., Hirata, A., Kusaka, I., Shinji, H., Morikawa, M., Yoshida, T., Isono, K., Yamasaki, M. Cell Struct. Funct. (1993) [Pubmed]
  14. Activation of STAT3 induced by cerebral ischemia in rat hippocampus and its possible mechanisms. Li, H.C., Zhang, G.Y. Sheng li xue bao [Acta physiologica Sinica]. (2003) [Pubmed]
  15. The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. Weiser, D.C., Sikes, S., Li, S., Shenolikar, S. J. Biol. Chem. (2004) [Pubmed]
  16. Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. Connor, J.H., Kleeman, T., Barik, S., Honkanen, R.E., Shenolikar, S. J. Biol. Chem. (1999) [Pubmed]
  17. Phosphorylation of tau at THR212 and SER214 in human neuronal and glial cultures: the role of AKT. Kyoung Pyo, H., Lovati, E., Pasinetti, G.M., Ksiezak-Reding, H. Neuroscience (2004) [Pubmed]
  18. Identification of brain-specific splicing variants of the hDLG1 gene and altered splicing in neuroblastoma cell lines. Mori, K., Iwao, K., Miyoshi, Y., Nakagawara, A., Kofu, K., Akiyama, T., Arita, N., Hayakawa, T., Nakamura, Y. J. Hum. Genet. (1998) [Pubmed]
  19. Isolation and functional characterization of cDNA of serum amyloid A-activating factor that binds to the serum amyloid A promoter. Ray, A., Ray, B.K. Mol. Cell. Biol. (1998) [Pubmed]
  20. Protein phosphatase inhibitor okadaic acid enhances transmitter release at neuromuscular junctions. Abdul-Ghani, M., Kravitz, E.A., Meiri, H., Rahamimoff, R. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  21. CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Krakstad, C., Herfindal, L., Gjertsen, B.T., Bøe, R., Vintermyr, O.K., Fladmark, K.E., Døskeland, S.O. Cell Death Differ. (2006) [Pubmed]
  22. Mitotic arrest and enhanced nuclear protein phosphorylation in human leukemia K562 cells by okadaic acid, a potent protein phosphatase inhibitor and tumor promoter. Zheng, B., Woo, C.F., Kuo, J.F. J. Biol. Chem. (1991) [Pubmed]
  23. The regulation of Na/K/2Cl cotransport and bumetanide binding in avian erythrocytes by protein phosphorylation and dephosphorylation. Effects of kinase inhibitors and okadaic acid. Pewitt, E.B., Hegde, R.S., Haas, M., Palfrey, H.C. J. Biol. Chem. (1990) [Pubmed]
  24. Dopamine regulation of amiloride-sensitive sodium channels in lung cells. Helms, M.N., Chen, X.J., Ramosevac, S., Eaton, D.C., Jain, L. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  25. Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells. Christoffersen, J., Smeland, E.B., Stokke, T., Taskén, K., Andersson, K.B., Blomhoff, H.K. Cancer Res. (1994) [Pubmed]
  26. Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes. de Carvalho, M.G., McCormack, A.L., Olson, E., Ghomashchi, F., Gelb, M.H., Yates, J.R., Leslie, C.C. J. Biol. Chem. (1996) [Pubmed]
  27. Hydrogen peroxide induces up-regulation of Fas in human endothelial cells. Suhara, T., Fukuo, K., Sugimoto, T., Morimoto, S., Nakahashi, T., Hata, S., Shimizu, M., Ogihara, T. J. Immunol. (1998) [Pubmed]
  28. Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly. Yamauchi, Y., Hayashi, M., Abe-Dohmae, S., Yokoyama, S. J. Biol. Chem. (2003) [Pubmed]
  29. The protein phosphatase inhibitor calyculin A stimulates chemokine production by human synovial cells. Jordan, N.J., Watson, M.L., Westwick, J. Biochem. J. (1995) [Pubmed]
  30. Cobalt chloride-induced signaling in endothelium leading to the augmented adherence of sickle red blood cells and transendothelial migration of monocyte-like HL-60 cells is blocked by PAF-receptor antagonist. Sultana, C., Shen, Y., Johnson, C., Kalra, V.K. J. Cell. Physiol. (1999) [Pubmed]
  31. Regulation of prostaglandin endoperoxide H2 synthase in term human gestational tissues. Zakar, T., Olson, D.M., Teixeira, F.J., Hirst, J.J. Acta physiologica Hungarica. (1996) [Pubmed]
  32. Differential expression of 1-aminocyclopropane-1-carboxylate synthase genes during orchid flower senescence induced by the protein phosphatase inhibitor okadaic acid. Wang, N.N., Yang, S.F., Charng , Y. Plant Physiol. (2001) [Pubmed]
  33. Regulation of LFA-1 avidity in human B cells. Requirements for dephosphorylation events for high avidity ICAM-1 binding. Hedman, H., Lundgren, E. J. Immunol. (1992) [Pubmed]
  34. Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins. Li, X., Song, S., Liu, Y., Ko, S.H., Kao, H.Y. J. Biol. Chem. (2004) [Pubmed]
  35. Cdk7- and Cdc25A-independent dephosphorylation of Cdk2 during phorbol ester-mediated cell cycle arrest in U937 cells. Kwon, T.K., Baek, S.H., Kim, J.H., Lee, S.J., Park, Y.K., Park, J.W., Kwun, K.B., Buchholz, M.A., Nordin, A.A. Exp. Cell Res. (2000) [Pubmed]
  36. Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis. Liu, W.J., Jiang, J.F., Xiao, D., Ding, J. Biochem. Pharmacol. (2002) [Pubmed]
  37. Identification and characterization of a radiation-inducible glycosylated human early-response gene. Kondratyev, A.D., Chung, K.N., Jung, M.O. Cancer Res. (1996) [Pubmed]
  38. Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. Kiguchi, K., Glesne, D., Chubb, C.H., Fujiki, H., Huberman, E. Cell Growth Differ. (1994) [Pubmed]
  39. Identification of the alternative splice products encoded by the human protein phosphatase inhibitor-1 gene. Liu, H.T., Lin, T.H., Kuo, H.C., Chen, Y.C., Tsay, H.J., Jeng, H.H., Tsai, P.C., Shie, F.K., Chen, J.H., Huang, H.B. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  40. Biotyping, serotyping and phage typing of Streptococcus faecalis isolated from dental plaque in the human mouth. Smyth, C.J., Matthews, H., Halpenny, M.K., Brandis, H., Colman, G. J. Med. Microbiol. (1987) [Pubmed]
  41. Reflex responses of the masseter muscle in patients with chronic arthritis or internal derangement of the temporomandibular joint. A comparison with symptomfree subjects. Bjørnland, T., Brodin, P., Larheim, T.A., Aars, H. Journal of oral rehabilitation. (1996) [Pubmed]
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