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Birosová, L. et al.

Birosová, Mikulásová,

Development of ciprofloxacin resistance due to chromosomal mutations induced by 2-nitrofluorene.

In this paper we investigated the ability of 2-nitrofluorene to induce mutations leading to antibiotic resistance in quinolone-sensitive strain Salmonella typhimurium. After preincubation of bacteria with 2-nitrofluorene, the frequency of mutation to ciprofloxacin resistance was 57 fold higher than in the case of spontaneous mutability. Some of resultant resistant colonies showed a great increase of ciprofloxacin MIC.[1]

References

Development of ciprofloxacin resistance due to chromosomal mutations induced by 2-nitrofluorene. Birosová, L., Mikulásová, M. Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia. (2005) [Pubmed]

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