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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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 Cohen,  
 

Nuclear receptor corepressors and PPARgamma.

The nuclear receptor corepressors NCoR and SMRT repress gene transcription by recruiting a histone deacetylase complex. Their roles in PPARgamma action have been controversial. Recent evidence, however, suggests that NCoR and SMRT repress PPARgamma-mediated transcriptional activity on specific promoters in the adipocyte. In addition, by repressing PPARgamma action, these corepressors inhibit the ability of adipocyte differentiation to proceed. A further understanding of corepressor action in the adipocyte will provide insight into the balance of forces regulating adipogenesis, insulin sensitivity, and Type 2 diabetes mellitus.[1]

References

  1. Nuclear receptor corepressors and PPARgamma. Cohen, R.N. Nuclear receptor signaling [electronic resource] : the e-journal of NURSA. (2006) [Pubmed]
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