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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Amino acid derivatives. Part I. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain.

A series of amino acid esters bearing coumarin (3-15) were synthesized and evaluated, in vitro, against HIV-1, and bovine viral diarrhea virus (BVDV). The in vitro cytotoxicity of 3-10 and 12 was assayed against a panel of tumor cell lines consisting of CD4 human T-cells. Compound 14 showed inhibition of HIV-1 with EC(50) > 1.6 mug mL(-1), meanwhile compound 9 exhibited activity against leukaemia ( MT4) with CC(50) = 24 mumol L(-1).[1]

References

  1. Amino acid derivatives. Part I. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain. Al-Masoudi, N.A., Al-Masoudi, I.A., Ali, I.A., Al-Soud, Y.A., Saeed, B., LA Colla, P. Acta pharmaceutica (Zagreb, Croatia) (2006) [Pubmed]
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