BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis.
The bone morphogenetic protein ( BMP) signaling pathway is essential during gastrulation for the generation of ventral mesoderm, which makes it a challenge to define functions for this pathway at later stages of development. We have established an approach to disrupt BMP signaling specifically in lateral mesoderm during somitogenesis, by targeting a dominant-negative BMP receptor to Lmo2+ cells in developing zebrafish embryos. This results in expansion of hematopoietic and endothelial cells, while restricting the expression domain of the pronephric marker pax2. 1. Expression of a constitutively active receptor and transplantation experiments were used to confirm that BMP signaling in lateral mesoderm restricts subsequent hemato-vascular development. The results show that the BMP signaling pathway continues to function after cells are committed to a lateral mesoderm fate, and influences subsequent lineage decisions by restricting hemato-vascular fate in favor of pronephric development.[1]References
- BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Gupta, S., Zhu, H., Zon, L.I., Evans, T. Development (2006) [Pubmed]
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