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Gene Review

bmp1l  -  bone morphogenetic protein 1, like

Danio rerio

Synonyms: bmp1, tolloid
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High impact information on bmp1l

  • Members of the bone morphogenetic protein (BMP) family actively promote ventral cell fates, such as epidermis and blood, in the vertebrate gastrula [1].
  • Definition of cell fates along the dorso-ventral axis depends on an antagonistic relationship between ventralizing transforming growth factor-beta superfamily members, the bone morphogenetic proteins and factors secreted from the dorsal organizer, such as Noggin and Chordin [2].
  • In the past year, a novel signal regulating the formation of neural crest cells has been identified, and advances have been made in uncovering roles for bone morphogenetic protein signals and for a transcription factor in the onset of neural crest migration [3].
  • During early zebrafish embryonic development, FGFs regulate dorsoventral patterning by controlling ventral bone morphogenetic protein (BMP) expression [4].
  • 1. Expression of a constitutively active receptor and transplantation experiments were used to confirm that BMP signaling in lateral mesoderm restricts subsequent hemato-vascular development [5].

Biological context of bmp1l


Anatomical context of bmp1l

  • We conclude that the role of Bmp signaling in the ventral and posterior mesoderm changes as gastrulation proceeds [10].
  • We also found that zbmp-2 was induced cell autonomously within the transplanted cells in the host ectoderm, suggesting that BMP cannot influence even the neighboring cells [11].
  • Sustained Bmp signaling is essential for cloaca development in zebrafish [12].
  • Expression of BMP signalling pathway members in the developing zebrafish inner ear and lateral line [13].
  • Our results provide insight into alk8-mediated BMP signaling gradients and the establishment of premigratory NCC mediolateral positioning, and extend the model for BMP patterning of the neural crest to include that of NCC-derived pharyngeal arch cartilages [14].

Associations of bmp1l with chemical compounds


Other interactions of bmp1l


  1. Patterning the zebrafish axial skeleton requires early chordin function. Fisher, S., Halpern, M.E. Nat. Genet. (1999) [Pubmed]
  2. Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Thisse, B., Wright, C.V., Thisse, C. Nature (2000) [Pubmed]
  3. Molecular control of neural crest formation, migration and differentiation. Christiansen, J.H., Coles, E.G., Wilkinson, D.G. Curr. Opin. Cell Biol. (2000) [Pubmed]
  4. Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Fürthauer, M., Lin, W., Ang, S.L., Thisse, B., Thisse, C. Nat. Cell Biol. (2002) [Pubmed]
  5. BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Gupta, S., Zhu, H., Zon, L.I., Evans, T. Development (2006) [Pubmed]
  6. Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. Little, S.C., Mullins, M.C. Development (2004) [Pubmed]
  7. Bmp activity gradient regulates convergent extension during zebrafish gastrulation. Myers, D.C., Sepich, D.S., Solnica-Krezel, L. Dev. Biol. (2002) [Pubmed]
  8. Conservation of BMP signaling in zebrafish mesoderm patterning. Nikaido, M., Tada, M., Saji, T., Ueno, N. Mech. Dev. (1997) [Pubmed]
  9. Specification of the enveloping layer and lack of autoneuralization in zebrafish embryonic explants. Sagerström, C.G., Gammill, L.S., Veale, R., Sive, H. Dev. Dyn. (2005) [Pubmed]
  10. Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development. Pyati, U.J., Webb, A.E., Kimelman, D. Development (2005) [Pubmed]
  11. In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning. Nikaido, M., Tada, M., Takeda, H., Kuroiwa, A., Ueno, N. Development (1999) [Pubmed]
  12. Sustained Bmp signaling is essential for cloaca development in zebrafish. Pyati, U.J., Cooper, M.S., Davidson, A.J., Nechiporuk, A., Kimelman, D. Development (2006) [Pubmed]
  13. Expression of BMP signalling pathway members in the developing zebrafish inner ear and lateral line. Mowbray, C., Hammerschmidt, M., Whitfield, T.T. Mech. Dev. (2001) [Pubmed]
  14. Alk8 is required for neural crest cell formation and development of pharyngeal arch cartilages. Payne-Ferreira, T.L., Yelick, P.C. Dev. Dyn. (2003) [Pubmed]
  15. The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Bauer, H., Lele, Z., Rauch, G.J., Geisler, R., Hammerschmidt, M. Development (2001) [Pubmed]
  16. Expression of the protein related to Dan and Cerberus gene-prdc-During eye, pharyngeal arch, somite, and swim bladder development in zebrafish. M??ller, I.I., Knapik, E.W., Hatzopoulos, A.K. Dev. Dyn. (2006) [Pubmed]
  17. Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling. Kramer, C., Mayr, T., Nowak, M., Schumacher, J., Runke, G., Bauer, H., Wagner, D.S., Schmid, B., Imai, Y., Talbot, W.S., Mullins, M.C., Hammerschmidt, M. Dev. Biol. (2002) [Pubmed]
  18. An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling. Oren, T., Torregroza, I., Evans, T. Nucleic Acids Res. (2005) [Pubmed]
  19. Three different noggin genes antagonize the activity of bone morphogenetic proteins in the zebrafish embryo. Fürthauer, M., Thisse, B., Thisse, C. Dev. Biol. (1999) [Pubmed]
  20. sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish. Fürthauer, M., Reifers, F., Brand, M., Thisse, B., Thisse, C. Development (2001) [Pubmed]
  21. The ventralizing activity of Radar, a maternally expressed bone morphogenetic protein, reveals complex bone morphogenetic protein interactions controlling dorso-ventral patterning in zebrafish. Goutel, C., Kishimoto, Y., Schulte-Merker, S., Rosa, F. Mech. Dev. (2000) [Pubmed]
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