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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Stimulation of lymphocyte natural cytotoxicity by L-arginine.

In vitro L-arginine enhanced natural-killer (NK) and lymphokine-activated-killer (LAK) cell activity; this cytotoxicity was mediated by CD56+ cells. In vivo arginine supplements (30 g/day for 3 days) increased the number of circulating CD56+ cells by a median of 32% in eight volunteers (p less than 0.01); this increase was associated with a mean rise of 91% in NK cell activity (p = 0.003) and of 58% in LAK cell activity (p = 0.001) in thirteen volunteers. These findings have potentially important implications for the modulation of natural cytotoxicity in a wide range of disease states.[1]


  1. Stimulation of lymphocyte natural cytotoxicity by L-arginine. Park, K.G., Hayes, P.D., Garlick, P.J., Sewell, H., Eremin, O. Lancet (1991) [Pubmed]
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