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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Plummer, E.R.

Plummer,

Inhibition of poly(ADP-ribose) polymerase in cancer.

Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase-1 ( PARP-1) has been extensively investigated in the pre-clinical setting as a strategy for chemo- or radio-potentiation. Recent evidence has suggested that PARP inhibitors might be active as single agents in certain rare inherited cancers that carry DNA repair defects. As a result, potent PARP-1 inhibitors have in the past three years entered early clinical trials in cancer patients, and the final results of these trials are eagerly awaited.[1]

References

Inhibition of poly(ADP-ribose) polymerase in cancer. Plummer, E.R. Current opinion in pharmacology. (2006) [Pubmed]

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