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MALDI Analysis of Oligonucleotides Directly from Montmorillonite.

Oligonucleotides synthesized on a montmorillonite catalyst were analyzed directly. By mixing the catalyst with a matrix (2,4,6-trihydroxyacetophenone or 6-aza-2-thiothymine) and dibasic ammonium citrate, higher molecular weight products were detected compared with "classical" methods such as gel electrophoresis and HPLC with UV as a detector. The oligomers (30-mers and higher) were detected by mass spectrometry even though their concentration was less than 10(-4)% of the total content of the RNA. This method is different from the (MALDI) analysis of the eluates from montmorillonite, which otherwise requires desalting. Placing reaction mixtures with a high concentration of buffers on homoionic, preferably Li-containing, montmorillonite does not require desalting.[1]

References

  1. MALDI Analysis of Oligonucleotides Directly from Montmorillonite. Zagorevskii, D.V., Aldersley, M.F., Ferris, J.P. J. Am. Soc. Mass Spectrom. (2006) [Pubmed]
 
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