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Chemical Compound Review:

NSC-1609 6-methyl-3-sulfanylidene-2H- 1,2,4-triazin...

Synonyms: AG-A-61134, ACMC-20am06, NSC-38618, NSC1609, SureCN11683953, ...

Zagorevskii, D.V. et al., Kirpekar, F. et al., Asara, J.M. et al., Papac, D.I. et al., Lecchi, P. et al.

Zagorevskii, Aldersley, Ferris, Kirpekar, Berkenkamp, Hillenkamp,

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High impact information on NSC 1609

Comatrixes such as ammonium salts with UV absorbers such as 3-hydroxypicolinic acid, 2,4,6-trihydroxyacetophenone, and 6-aza-2-thiothymine have been used to improve the spectral quality for oligonucleotides in MALDI MS [1].
In the lower mass range (up to approximately 70 base pairs), UV-MALDI with 6-aza-2-thiothymine as matrix was the ionization method of choice because it allowed specific double-stranded complexes containing relatively few base pairs to be desorbed intactly [2].
Negative-ion spectra of pure mono-, di-, and trisialylated oligosaccharides were acquired with either 6-aza-2-thiothymine or 2',4',6'-trihydroxyacetophenone (THAP) in the linear mode [3].
By mixing the catalyst with a matrix (2,4,6-trihydroxyacetophenone or 6-aza-2-thiothymine) and dibasic ammonium citrate, higher molecular weight products were detected compared with "classical" methods such as gel electrophoresis and HPLC with UV as a detector [4].

Analytical, diagnostic and therapeutic context of NSC 1609

6-Aza-2-thiothymine: a matrix for MALDI spectra of oligonucleotides [5].

References

Enhanced detection of oligonucleotides in UV MALDI MS using the tetraamine spermine as a matrix additive. Asara, J.M., Allison, J. Anal. Chem. (1999) [Pubmed]
Detection of double-stranded DNA by IR- and UV-MALDI mass spectrometry. Kirpekar, F., Berkenkamp, S., Hillenkamp, F. Anal. Chem. (1999) [Pubmed]
Analysis of acidic oligosaccharides and glycopeptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Papac, D.I., Wong, A., Jones, A.J. Anal. Chem. (1996) [Pubmed]
MALDI Analysis of Oligonucleotides Directly from Montmorillonite. Zagorevskii, D.V., Aldersley, M.F., Ferris, J.P. J. Am. Soc. Mass Spectrom. (2006) [Pubmed]
6-Aza-2-thiothymine: a matrix for MALDI spectra of oligonucleotides. Lecchi, P., Le, H.M., Pannell, L.K. Nucleic Acids Res. (1995) [Pubmed]

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