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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Psychometric scores and persistence of irritable bowel after infectious diarrhoea K. A. Geww, J. C. Graham, M. W. McKendrick, S. M. Collins, J. S. Marshall, S. J. Walters, N. R. Read Lancet 1996; 347: 150-153.

BACKGROUND: Although previous studies have shown that psychological disturbances are frequently associated with the irritable bowel syndrome (IBS), the relation was not necessarily cause and effect. The development of chronic bowel symptoms after an episode of acute gastroenteritis has allowed us to examine prospectively the role of psychological factors. METHODS: Seventy-five patients with acute gastroenteritis completed a series of psychometric tests soon after admission to hospital. Of these, 22 had persistent symptoms compatible with IBS after the acute illness, and in 20 of these the symptoms were still present at six months. FINDINGS: At the time of their initial illness, patients who subsequently developed IBS had higher scores for anxiety, depression, somatization and neurotic trait than those who returned to normal bowel function. The psychometric scores had not changed when remeasured after the acute illness. Lactose malabsorption was not an important factor. INTERPRETATION: These results support the hypothesis that psychological factors are important in IBS.[1]


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