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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Human Leukocyte Antigen F Protein is Expressed in the Extra-Villous Trophoblasts but Not on the Cell Surface of them.

Human leukocyte antigen (HLA)-F together with other class 1b HLAs may play a pivotal role in immunological interaction at feto-maternal interface. However, it is not elucidated whether HLA-F is expressed on cell surface of extra-villous trophoblasts (EVTs). The localization of HLA-F in placenta of each trimester was investigated by immunohistochemistry. The expression modality of HLA-F molecule was compared with that of HLA-G in cultured EVTs using flowcytometry. In immunohistochemical study, remarkable staining for HLA-F was confirmed in EVTs throughout gestation. HLA-F expression was restricted to be intracellular in cultured EVTs. HLA-F expression was increased with time in culture, which was accompanied by the increase of cell surface HLA-G. Consequently, HLA-F lacking in cell surface expression on EVTs may not contribute to the direct cell-to-cell immune reaction but might work supportively modifying the function of HLA-G.[1]

References

  1. Human Leukocyte Antigen F Protein is Expressed in the Extra-Villous Trophoblasts but Not on the Cell Surface of them. Nagamatsu, T., Fujii, T., Matsumoto, J., Yamashita, T., Kozuma, S., Taketani, Y. Am. J. Reprod. Immunol. (2006) [Pubmed]
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