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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity.

A hallmark of the immune system is the ability to ignore self-antigens. In attempts to bypass normal immune tolerance, a post-translational protein modification was introduced into self-antigens to break T and B cell tolerance. We demonstrate that immune tolerance is bypassed by immunization with a post-translationally modified melanoma antigen. In particular, the conversion of an aspartic acid to an isoaspartic acid within the melanoma antigen tyrosinase-related protein (TRP)-2 peptide-(181-188) makes the otherwise immunologically ignored TRP-2 antigen immunogenic. Tetramer analysis of iso-Asp TRP-2 peptide-immunized mice demonstrated that CD8(+) T cells not only recognized the isoaspartyl TRP-2 peptide but also the native TRP-2 peptide. These CD8(+) T cells functioned as cytotoxic T lymphocytes, as they effectively lysed TRP-2 peptide-pulsed targets both in vitro and in vivo. Potentially, post-translational protein modification can be utilized to trigger strong immune responses to either tumor proteins or potentially weakly immunogenic pathogens.[1]

References

  1. Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity. Doyle, H.A., Zhou, J., Wolff, M.J., Harvey, B.P., Roman, R.M., Gee, R.J., Koski, R.A., Mamula, M.J. J. Biol. Chem. (2006) [Pubmed]
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