The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Immune Tolerance

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Immune Tolerance


High impact information on Immune Tolerance

  • The protective effect may be explained by higher levels of class III VNTR-associated INS mRNA in thymus such that elevated levels of preproinsulin protein enhance immune tolerance to preproinsulin, a key autoantigen in type 1 diabetes pathogenesis [6].
  • Insulin was detected in all thymus tissues examined and class III VNTR alleles were associated with 2- to 3-fold higher INS mRNA levels than class I. We therefore propose higher levels of thymic INS expression, facilitating immune tolerance induction, as a mechanism for the dominant protective effect of class III alleles [7].
  • A critical role for Stat3 signaling in immune tolerance [8].
  • Regulatory T cells (T(reg) cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant immune tolerance to self [9].
  • If the assumption that immune tolerance determines the range of anti-Gal specificity is correct, then anti-Gal from individuals lacking the B antigen (A and O blood types) would be expected to interact with both Gal alpha 1----3Gal and Gal alpha 1----3(Fuc alpha 1----2)Gal epitopes [10].

Chemical compound and disease context of Immune Tolerance


Biological context of Immune Tolerance


Anatomical context of Immune Tolerance


Associations of Immune Tolerance with chemical compounds


Gene context of Immune Tolerance


Analytical, diagnostic and therapeutic context of Immune Tolerance


  1. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. Subudhi, S.K., Zhou, P., Yerian, L.M., Chin, R.K., Lo, J.C., Anders, R.A., Sun, Y., Chen, L., Wang, Y., Alegre, M.L., Fu, Y.X. J. Clin. Invest. (2004) [Pubmed]
  2. The protooncogene MYC can break B cell tolerance. Refaeli, Y., Field, K.A., Turner, B.C., Trumpp, A., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A. Rossi, G., Sarkar, J., Scandella, D. Blood (2001) [Pubmed]
  4. Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model. Trop, S., Samsonov, D., Gotsman, I., Alper, R., Diment, J., Ilan, Y. Hepatology (1999) [Pubmed]
  5. Cutting edge: diminished T cell TLR expression and function modulates the immune response in human filarial infection. Babu, S., Blauvelt, C.P., Kumaraswami, V., Nutman, T.B. J. Immunol. (2006) [Pubmed]
  6. Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group. Bennett, S.T., Wilson, A.J., Esposito, L., Bouzekri, N., Undlien, D.E., Cucca, F., Nisticò, L., Buzzetti, R., Bosi, E., Pociot, F., Nerup, J., Cambon-Thomsen, A., Pugliese, A., Shield, J.P., McKinney, P.A., Bain, S.C., Polychronakos, C., Todd, J.A. Nat. Genet. (1997) [Pubmed]
  7. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Vafiadis, P., Bennett, S.T., Todd, J.A., Nadeau, J., Grabs, R., Goodyer, C.G., Wickramasinghe, S., Colle, E., Polychronakos, C. Nat. Genet. (1997) [Pubmed]
  8. A critical role for Stat3 signaling in immune tolerance. Cheng, F., Wang, H.W., Cuenca, A., Huang, M., Ghansah, T., Brayer, J., Kerr, W.G., Takeda, K., Akira, S., Schoenberger, S.P., Yu, H., Jove, R., Sotomayor, E.M. Immunity (2003) [Pubmed]
  9. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Fontenot, J.D., Rasmussen, J.P., Gavin, M.A., Rudensky, A.Y. Nat. Immunol. (2005) [Pubmed]
  10. The human natural anti-Gal IgG. III. The subtlety of immune tolerance in man as demonstrated by crossreactivity between natural anti-Gal and anti-B antibodies. Galili, U., Buehler, J., Shohet, S.B., Macher, B.A. J. Exp. Med. (1987) [Pubmed]
  11. Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)-uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection. Menne, S., Roneker, C.A., Korba, B.E., Gerin, J.L., Tennant, B.C., Cote, P.J. J. Virol. (2002) [Pubmed]
  12. T-Cell suicide gene therapy for organ transplantation: induction of long-lasting tolerance to allogeneic heart without generalized immunosuppression. Braunberger, E., Cohen, J.L., Boyer, O., Pegaz-Fiornet, B., Raynal-Raschilas, N., Bruneval, P., Thomas-Vaslin, V., Bellier, B., Carpentier, A., Glotz, D., Klatzmann, D. Mol. Ther. (2000) [Pubmed]
  13. Complete remission and possible immune tolerance after multidrug combination chemotherapy for cyclosporine-related lymphoma in a renal transplant recipient with acute pancreatitis. Lien, Y.H., Schröter, G.P., Weil, R., Robinson, W.A. Transplantation (1991) [Pubmed]
  14. Immune tolerance in a haemophilia A patient with high inhibitor using locally prepared lyophilized cryoprecipitate. Chuansumrit, A., Pakakasama, S., Kuhathong, K., Chantanakajornfung, A., Hathirat, P. Haemophilia : the official journal of the World Federation of Hemophilia. (2000) [Pubmed]
  15. HLA-G gene repression is reversed by demethylation. Moreau, P., Mouillot, G., Rousseau, P., Marcou, C., Dausset, J., Carosella, E.D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. In utero gene transfer of human factor IX to fetal mice can induce postnatal tolerance of the exogenous clotting factor. Waddington, S.N., Buckley, S.M., Nivsarkar, M., Jezzard, S., Schneider, H., Dahse, T., Kemball-Cook, G., Miah, M., Tucker, N., Dallman, M.J., Themis, M., Coutelle, C. Blood (2003) [Pubmed]
  17. A deficiency of placental IL-10 in preeclampsia. Hennessy, A., Pilmore, H.L., Simmons, L.A., Painter, D.M. J. Immunol. (1999) [Pubmed]
  18. Immune tolerance to combined organ and bone marrow transplants after fractionated lymphoid irradiation involves regulatory NK T cells and clonal deletion. Higuchi, M., Zeng, D., Shizuru, J., Gworek, J., Dejbakhsh-Jones, S., Taniguchi, M., Strober, S. J. Immunol. (2002) [Pubmed]
  19. Placental Fas ligand expression is a mechanism for maternal immune tolerance to the fetus. Kauma, S.W., Huff, T.F., Hayes, N., Nilkaeo, A. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  20. Is transplantation tolerable? Strom, T.B. J. Clin. Invest. (2004) [Pubmed]
  21. Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. Delarasse, C., Daubas, P., Mars, L.T., Vizler, C., Litzenburger, T., Iglesias, A., Bauer, J., Della Gaspera, B., Schubart, A., Decker, L., Dimitri, D., Roussel, G., Dierich, A., Amor, S., Dautigny, A., Liblau, R., Pham-Dinh, D. J. Clin. Invest. (2003) [Pubmed]
  22. Outcome of Kupffer cell antigen presentation to a cloned murine Th1 lymphocyte depends on the inducibility of nitric oxide synthase by IFN-gamma. Roland, C.R., Walp, L., Stack, R.M., Flye, M.W. J. Immunol. (1994) [Pubmed]
  23. Dendritic cell differentiation and immune tolerance to insulin-related peptides in Igf2-deficient mice. Hansenne, I., Renard-Charlet, C., Greimers, R., Geenen, V. J. Immunol. (2006) [Pubmed]
  24. Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system. Kayisli, U.A., Selam, B., Guzeloglu-Kayisli, O., Demir, R., Arici, A. J. Immunol. (2003) [Pubmed]
  25. Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouse. Palmer, J.M., Robe, A.J., Burt, A.D., Kirby, J.A., Jones, D.E. Hepatology (2004) [Pubmed]
  26. Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. Kusmartsev, S.A., Li, Y., Chen, S.H. J. Immunol. (2000) [Pubmed]
  27. Blockade of CD40 pathway enhances the induction of immune tolerance by immature dendritic cells genetically modified to express cytotoxic T lymphocyte antigen 4 immunoglobulin. Sun, W., Wang, Q., Zhang, L., Liu, Y., Zhang, M., Wang, C., Wang, J., Cao, X. Transplantation (2003) [Pubmed]
  28. Induction of tolerance to poison ivy urushiol in the guinea pig by epicutaneous application of the structural analog 5-methyl-3-n-pentadecylcatechol. Stampf, J.L., Benezra, C., Byers, V., Castagnoli, N. J. Invest. Dermatol. (1986) [Pubmed]
  29. Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines. Weber, W.P., Feder-Mengus, C., Chiarugi, A., Rosenthal, R., Reschner, A., Schumacher, R., Zajac, P., Misteli, H., Frey, D.M., Oertli, D., Heberer, M., Spagnoli, G.C. Eur. J. Immunol. (2006) [Pubmed]
  30. Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. Murumägi, A., Vähämurto, P., Peterson, P. J. Biol. Chem. (2003) [Pubmed]
  31. Ultraviolet light-induced immune tolerance is mediated via the Fas/Fas-ligand system. Schwarz, A., Grabbe, S., Grosse-Heitmeyer, K., Roters, B., Riemann, H., Luger, T.A., Trinchieri, G., Schwarz, T. J. Immunol. (1998) [Pubmed]
  32. Molecular mechanisms underlying FOXP3 induction in human T cells. Mantel, P.Y., Ouaked, N., Rückert, B., Karagiannidis, C., Welz, R., Blaser, K., Schmidt-Weber, C.B. J. Immunol. (2006) [Pubmed]
  33. The murine family of gut-restricted class Ib MHC includes alternatively spliced isoforms of the proposed HLA-G homolog, "blastocyst MHC". Guidry, P.A., Stroynowski, I. J. Immunol. (2005) [Pubmed]
  34. Dendritic cells pulsed with an anti-idiotype antibody mimicking carcinoembryonic antigen (CEA) can reverse immunological tolerance to CEA and induce antitumor immunity in CEA transgenic mice. Saha, A., Chatterjee, S.K., Foon, K.A., Primus, F.J., Sreedharan, S., Mohanty, K., Bhattacharya-Chatterjee, M. Cancer Res. (2004) [Pubmed]
  35. Fas ligand as a tool for immunosuppression and generation of immune tolerance. Bohana-Kashtan, O., Civin, C.I. Stem Cells (2004) [Pubmed]
  36. Antigen-driven peripheral immune tolerance: suppression of experimental autoimmmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen. al-Sabbagh, A., Nelson, P.A., Akselband, Y., Sobel, R.A., Weiner, H.L. Cell. Immunol. (1996) [Pubmed]
  37. Immune tolerance induced by donor antigen and cyclophosphamide in rat fetal small bowel transplantation. Nakao, M., Taguchi, T., Ogita, K., Nishimoto, Y., Suita, S. Fukuoka Igaku Zasshi (2005) [Pubmed]
  38. Influence of recipient pretreatment with donor spleen cells and 15-deoxyspergualin on rat skin graft survival. Krzymański, M., Oko, A., Waaga, A.M., Pawliczak, E., Wiktorowicz, K. Arch. Immunol. Ther. Exp. (Warsz.) (1997) [Pubmed]
WikiGenes - Universities