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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Datura stramonium agglutinin-reactive alpha-fetoprotein isoforms in hepatocellular carcinoma and other tumors.

By means of Datura stramonium agglutinin (DSA) affinity electrophoresis, human alpha-fetoprotein ( AFP) was resolved into five bands, AFP-D1, D2, D3, D4 and D5, in order of decreasing mobility. AFP-D1, which had no affinity for DSA, comprised more than 84% of the intensity of total AFP bands. The percentage of AFP-D2 increased marginally in hepatitis and liver cirrhosis with or without hepatocellular carcinoma. AFP-D3 increased characteristically in hepatocellular carcinoma and AFP-D4, which had the highest affinity for DSA, increased up to 12% in other tumors, mostly of gastrointestinal origin. AFP-D5 showed no consistent changes among the benign and malignant diseases. The assay of AFP-D3 and D4 proved useful as a highly specific marker of hepatocellular carcinoma and other tumors, respectively.[1]

References

  1. Datura stramonium agglutinin-reactive alpha-fetoprotein isoforms in hepatocellular carcinoma and other tumors. Taketa, K., Ichikawa, E., Yamamoto, T., Kato, H., Matsuura, S., Taga, H., Hirai, H. Tumour Biol. (1990) [Pubmed]
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