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MeSH Review

Datura stramonium

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Disease relevance of Datura stramonium

  • Jimson weed seed meal, which contains alkaloids toxic to animals, and cocoa shell meal, which contains theobromine, also toxic to animals, were used in two experiments with broilers to determine relative toxicity [1].
  • No congenital arthrogryposis or other deformities were found in newborn Hampshire pigs born to sows administered Datura stramonium (jimsonweed) during the second or third months of pregnancy at levels producing marked clinical signs of toxicity in the dams [2].

High impact information on Datura stramonium

  • The D2-dopamine receptor from bovine anterior pituitary has been purified approximately 33,000-fold to apparent homogeneity by sequential use of affinity chromatography on immobilized carboxymethyleneoximinospiperone-Sepharose, Datura stramonium lectin-agarose, and hydroxylapatite chromatography [3].
  • Older anticholinergic agents such as stramonium and atropine have significant non-pulmonary effects [4].
  • We demonstrate that overexpression of the D. stramonium samdc cDNA in transgenic rice is sufficient for accumulation of spermidine in leaves and spermidine and spermine in seeds [5].
  • Here we use antibodies against glutamine synthetase full-length molecule (anti-GS/FL), a GS C-terminal peptide (anti-GS/20aa-C), and brain S100 (anti-S100), as well as the binding of the insect glia and rat astrocytic marker Datura stramonium lectin (DSL), in the optic lobe of the prawn Macrobrachium rosenbergii [6].
  • Serum transferrin and the partially purified serum CDT were investigated by concanavalin A (Con A)- and Datura stramonium agglutinin (DSA)-affinity electrophoresis followed by antibody-affinity blotting and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with Western blotting [7].

Biological context of Datura stramonium


Anatomical context of Datura stramonium


Associations of Datura stramonium with chemical compounds


Gene context of Datura stramonium

  • Western- and lectin-blotting of the shed coat material demonstrated 2 prominent entities; a 90 kDa glycoprotein, which bound Datura stramonium agglutinin and was resistant to N- and O-glycanase treatment and a 47-60 kDa set of protein(s) [15].
  • While each glycoprotein fraction was bound to Datura stramonium lectin, they failed to react with anti-[i-(Den)] serum and their digestion with endo-beta-galactosidase did not cause a band shift in SDS/PAGE [16].
  • Datura stramonium agglutinin-reactive alpha-fetoprotein isoforms in hepatocellular carcinoma and other tumors [17].
  • To investigate critically whether constitutive overexpression of ODC is sufficient to control steady-state polyamine levels, we expressed an ODC cDNA from Datura stramonium in transgenic tobacco plants [18].
  • GnT-V activity increased to approximately two- to three-fold the initial level with increasing mRNA level after 8 days, and lectin blot analysis showed an increase in reactivity to Datsura stramonium (DSA) of the immunoprecipitated neural cell adhesion molecule (NCAM) [19].

Analytical, diagnostic and therapeutic context of Datura stramonium


  1. Toxicity of jimson weed seed and cocoa shell meal to broilers. Day, E.J., Dilworth, B.C. Poult. Sci. (1984) [Pubmed]
  2. Absence of arthrogryposis in newborn Hampshire pigs from sows ingesting toxic levels of jimsonweed during gestation. Keeler, R.F. Veterinary and human toxicology. (1981) [Pubmed]
  3. Purification and characterization of the D2-dopamine receptor from bovine anterior pituitary. Senogles, S.E., Amlaiky, N., Falardeau, P., Caron, M.G. J. Biol. Chem. (1988) [Pubmed]
  4. Hemodynamic and non-bronchial effects of ipratropium bromide. Anderson, W.M. Am. J. Med. (1986) [Pubmed]
  5. Expression of a heterologous S-adenosylmethionine decarboxylase cDNA in plants demonstrates that changes in S-adenosyl-L-methionine decarboxylase activity determine levels of the higher polyamines spermidine and spermine. Thu-Hang, P., Bassie, L., Safwat, G., Trung-Nghia, P., Christou, P., Capell, T. Plant Physiol. (2002) [Pubmed]
  6. Regionally specific distribution of the binding of anti-glutamine synthetase and anti-S100 antibodies and of Datura stramonium lectin in glial domains of the optic lobe of the giant prawn. Allodi, S., Bressan, C.M., Carvalho, S.L., Cavalcante, L.A. Glia (2006) [Pubmed]
  7. Structural studies on sugar chains of carbohydrate-deficient transferrin from patients with alcoholic liver disease using lectin affinity electrophoresis. Inoue, T., Yamauchi, M., Ohkawa, K. Electrophoresis (1999) [Pubmed]
  8. Characterization of glycoconjugate expression during development of Meckel's cartilage in the rat. Zschäbitz, A., Weiser, H., Stofft, E., Krahn, V., Gabius, H.J., Khaw, A., Biesalski, H.K. Anat. Embryol. (1995) [Pubmed]
  9. Mutational analysis of bean yellow dwarf virus, a geminivirus of the genus Mastrevirus that is adapted to dicotyledonous plants. Liu, L., Davies, J.W., Stanley, J. J. Gen. Virol. (1998) [Pubmed]
  10. Benzalkonium chloride inhibited the histamine release from rat peritoneal mast cells induced by bradykinin and GlcNAc oligomer-specific lectin Datura stramonium agglutinin, but heparin did not. Niitsuma, A., Uchida, M.K., Suzuki-Nishimura, T. Gen. Pharmacol. (1996) [Pubmed]
  11. Purification of the lectin from Datura stramonium. Kilpatrick, D.C., Yeoman, M.M. Biochem. J. (1978) [Pubmed]
  12. The macrophage cell surface glycoprotein F4/80 is a highly glycosylated proteoglycan. Haidl, I.D., Jefferies, W.A. Eur. J. Immunol. (1996) [Pubmed]
  13. Evolutionary ecology of the tropane alkaloids of Datura stramonium L. (Solanaceae). Shonle, I., Bergelson, J. Evolution (2000) [Pubmed]
  14. The formation of 3 alpha- and 3 beta-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases. Robins, R.J., Bachmann, P., Robinson, T., Rhodes, M.J., Yamada, Y. FEBS Lett. (1991) [Pubmed]
  15. The surface coat of infective larvae of Trichinella spiralis. Modha, J., Roberts, M.C., Robertson, W.M., Sweetman, G., Powell, K.A., Kennedy, M.W., Kusel, J.R. Parasitology (1999) [Pubmed]
  16. alpha-D-galactose-bearing glycoproteins on the surface of stimulated murine peritoneal macrophages. Biochemical and immunochemical characterization of purified glycoproteins. Petryniak, J., Huard, T.K., Goldstein, I.J. Eur. J. Biochem. (1992) [Pubmed]
  17. Datura stramonium agglutinin-reactive alpha-fetoprotein isoforms in hepatocellular carcinoma and other tumors. Taketa, K., Ichikawa, E., Yamamoto, T., Kato, H., Matsuura, S., Taga, H., Hirai, H. Tumour Biol. (1990) [Pubmed]
  18. Polyamine homeostasis in transgenic plants overexpressing ornithine decarboxylase includes ornithine limitation. Mayer, M.J., Michael, A.J. J. Biochem. (2003) [Pubmed]
  19. Effects of dibutyryl cAMP and bromodeoxyuridine on expression of N-acetylglucosaminyltransferases III and V in GOTO neuroblastoma cells. Ihara, Y., Nishikawa, A., Taniguchi, N. Glycoconj. J. (1995) [Pubmed]
  20. Crystallization and preliminary crystallographic study of tropinone reductase II from Datura stramonium. Yamashita, A., Nakajima, K., Kato, H., Hashimoto, T., Yamada, Y., Oda, J. Acta Crystallogr. D Biol. Crystallogr. (1998) [Pubmed]
  21. Expression and characterization of a lactosaminoglycan-carrying glycoprotein of Zajdela hepatoma cell surface--structural analysis of the carbohydrate moiety. Goulut-Chassaing, C., Bourrillon, R. Eur. J. Biochem. (1997) [Pubmed]
  22. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry. Steenkamp, P.A., Harding, N.M., van Heerden, F.R., van Wyk, B.E. Forensic Sci. Int. (2004) [Pubmed]
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