Gene Review:
AFP - alpha-fetoprotein
Homo sapiens
Synonyms:
AFPD, Alpha-1-fetoprotein, Alpha-fetoglobulin, Alpha-fetoprotein, FETA, ...
- In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin-2. Bui, L.A., Butterfield, L.H., Kim, J.Y., Ribas, A., Seu, P., Lau, R., Glaspy, J.A., McBride, W.H., Economou, J.S. Hum. Gene Ther. (1997)
- Different characteristics of hepatoid and non-hepatoid alpha-fetoprotein-producing gastric carcinomas: an experimental study using xenografted tumors. Aizawa, K., Motoyama, T., Suzuki, S., Tanaka, N., Yabusaki, H., Tanaka, S., Muto, I., Tanaka, O., Hatakeyama, K. Int. J. Cancer (1994)
- High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and beta-catenin mutations. Peng, S.Y., Chen, W.J., Lai, P.L., Jeng, Y.M., Sheu, J.C., Hsu, H.C. Int. J. Cancer (2004)
- High frequency of c-Met expression in gastric cancers producing alpha- fetoprotein. Amemiya, H., Kono, K., Mori, Y., Takahashi, A., Ichihara, F., Iizuka, H., Sekikawa, T., Matsumoto, Y. Oncology (2000)
- Frequency and phenotypic spectrum of ataxia with oculomotor apraxia 2: a clinical and genetic study in 18 patients. Le Ber, I., Bouslam, N., Rivaud-Péchoux, S., Guimarães, J., Benomar, A., Chamayou, C., Goizet, C., Moreira, M.C., Klur, S., Yahyaoui, M., Agid, Y., Koenig, M., Stevanin, G., Brice, A., Dürr, A. Brain (2004)
- Diagnosis of premature rupture of membranes with an improved alpha-fetoprotein monoclonal antibody kit. Kishida, T., Hirao, A., Matsuura, T., Katamine, T., Yamada, H., Sagawa, T., Fujimoto, S. Clin. Chem. (1995)
- Serum alpha-fetoprotein levels and liver histology in patients with chronic hepatitis C. Bayati, N., Silverman, A.L., Gordon, S.C. Am. J. Gastroenterol. (1998)
- A multidirectional sonographic approach to elevated amniotic alpha-fetoprotein or positive acetylcholinesterase. Blumenfeld, Z., Zimmer, E., Bronshtein, M. Obstetrics and gynecology. (1995)
- Alpha fetoprotein screening and diagnosis of fetal open neural tube defects: the need for quality control. Wald, N.J., Cuckle, H.S., Catz, C., Dayton, D., Reimer, C.B. Am. J. Obstet. Gynecol. (1981)
- Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2. Moreira, M.C., Klur, S., Watanabe, M., Németh, A.H., Le Ber, I., Moniz, J.C., Tranchant, C., Aubourg, P., Tazir, M., Schöls, L., Pandolfo, M., Schulz, J.B., Pouget, J., Calvas, P., Shizuka-Ikeda, M., Shoji, M., Tanaka, M., Izatt, L., Shaw, C.E., M'Zahem, A., Dunne, E., Bomont, P., Benhassine, T., Bouslam, N., Stevanin, G., Brice, A., Guimarães, J., Mendonça, P., Barbot, C., Coutinho, P., Sequeiros, J., Dürr, A., Warter, J.M., Koenig, M. Nat. Genet. (2004)
- Integrated screening for Down's syndrome on the basis of tests performed during the first and second trimesters. Wald, N.J., Watt, H.C., Hackshaw, A.K. N. Engl. J. Med. (1999)
- Increased nuchal translucency as a marker for fetal chromosomal defects. Taipale, P., Hiilesmaa, V., Salonen, R., Ylöstalo, P. N. Engl. J. Med. (1997)
- Dimeric inhibin A as a marker for Down's syndrome in early pregnancy. Aitken, D.A., Wallace, E.M., Crossley, J.A., Swanston, I.A., van Pareren, Y., van Maarle, M., Groome, N.P., Macri, J.N., Connor, J.M. N. Engl. J. Med. (1996)
- Alpha-fetoprotein-producing gastric cancer: histochemical analysis of cell proliferation, apoptosis, and angiogenesis. Koide, N., Nishio, A., Igarashi, J., Kajikawa, S., Adachi, W., Amano, J. Am. J. Gastroenterol. (1999)
- Prevention of N-methyl-N-nitrosourea-induced breast cancer by alpha-fetoprotein (AFP)-derived peptide, a peptide derived from the active site of AFP. Parikh, R.R., Gildener-Leapman, N., Narendran, A., Lin, H.Y., Lemanski, N., Bennett, J.A., Jacobson, H.I., Andersen, T.T. Clin. Cancer Res. (2005)
- The enzymatic basis for the conversion of nonfucosylated to fucosylated alpha-fetoprotein by acyclic retinoid treatment in human hepatoma cells: activation of alpha1-6 fucosyltransferase. Noda, K., Miyoshi, E., Kitada, T., Nakahara, S., Gao, C.X., Honke, K., Shiratori, Y., Moriwaki, H., Sasaki, Y., Kasahara, A., Hori, M., Hayashi, N., Taniguchi, N. Tumour Biol. (2002)
- Immunohistochemical expression of pi class glutathione S-transferase and alpha-fetoprotein in hepatocellular carcinoma and chronic liver disease. Yusof, Y.A., Yan, K.L., Hussain, S.N. Anal. Quant. Cytol. Histol. (2003)
- Epithelial layer formation in differentiating aggregates of F9 embryonal carcinoma cells. Grover, A., Oshima, R.G., Adamson, E.D. J. Cell Biol. (1983)
- p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding. Lee, K.C., Crowe, A.J., Barton, M.C. Mol. Cell. Biol. (1999)
- Oncodevelopmental alpha-fetoprotein acts as a selective proangiogenic factor on endothelial cell from the fetomaternal unit. Liang, O.D., Korff, T., Eckhardt, J., Rifaat, J., Baal, N., Herr, F., Preissner, K.T., Zygmunt, M. J. Clin. Endocrinol. Metab. (2004)
- Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription. Nishio, H., Heiskanen, M., Palotie, A., Bélanger, L., Dugaiczyk, A. J. Mol. Biol. (1996)
- The phylogeny of alpha-fetoprotein in vertebrates: survey of biochemical and physiological data. Mizejewski, G.J. Crit. Rev. Eukaryot. Gene Expr. (1995)
- ING1 represses transcription by direct DNA binding and through effects on p53. Kataoka, H., Bonnefin, P., Vieyra, D., Feng, X., Hara, Y., Miura, Y., Joh, T., Nakabayashi, H., Vaziri, H., Harris, C.C., Riabowol, K. Cancer Res. (2003)
- Human alpha fetoprotein enhances epidermal growth factor proliferative activity upon porcine granulosa cells in monolayer culture. Leal, J.A., May, J.V., Keel, B.A. Endocrinology (1990)
- Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription. Cui, R., Nguyen, T.T., Taube, J.H., Stratton, S.A., Feuerman, M.H., Barton, M.C. J. Biol. Chem. (2005)
- Amelioration of autoimmune neuroinflammation by recombinant human alpha-fetoprotein. Irony-Tur-Sinai, M., Grigoriadis, N., Lourbopoulos, A., Pinto-Maaravi, F., Abramsky, O., Brenner, T. Exp. Neurol. (2006)
- Expression of alpha-fetoprotein and interleukin 2 receptors and impairment of membrane fluidity in peripheral blood mononuclear cells from AIDS and related syndromes. Macho, A., Aguilar, J.J., Naval, J., Girard, P.M., Uriel, J. AIDS Res. Hum. Retroviruses (1994)
- Spindle cell hepatocellular carcinoma. A clinicopathologic and immunohistochemical analysis of 15 cases. Maeda, T., Adachi, E., Kajiyama, K., Takenaka, K., Sugimachi, K., Tsuneyoshi, M. Cancer (1996)
- The impact of waiting list alpha-fetoprotein changes on the outcome of liver transplant for hepatocellular carcinoma. Merani, S., Majno, P., Kneteman, N.M., Berney, T., Morel, P., Mentha, G., Toso, C. J. Hepatol. (2011)
- Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma. Personeni, N., Bozzarelli, S., Pressiani, T., Rimassa, L., Tronconi, M.C., Sclafani, F., Carnaghi, C., Pedicini, V., Giordano, L., Santoro, A. J. Hepatol. (2012)
- Human alpha-fetoprotein binds to primary macrophages. Atemezem, A., Mbemba, E., Marfaing, R., Vaysse, J., Pontet, M., Saffar, L., Charnaux, N., Gattegno, L. Biochem. Biophys. Res. Commun. (2002)
- A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers. Morinaga, T., Yasuda, H., Hashimoto, T., Higashio, K., Tamaoki, T. Mol. Cell. Biol. (1991)
- 18F-labeled difluoroestradiols: preparation and preclinical evaluation as estrogen receptor-binding radiopharmaceuticals. Seimbille, Y., Rousseau, J., Bénard, F., Morin, C., Ali, H., Avvakumov, G., Hammond, G.L., van Lier, J.E. Steroids (2002)
- Members of the CAAT/enhancer-binding protein, hepatocyte nuclear factor-1 and nuclear factor-1 families can differentially modulate the activities of the rat alpha-fetoprotein promoter and enhancer. Bois-Joyeux, B., Danan, J.L. Biochem. J. (1994)
- p53 targets chromatin structure alteration to repress alpha-fetoprotein gene expression. Ogden, S.K., Lee, K.C., Wernke-Dollries, K., Stratton, S.A., Aronow, B., Barton, M.C. J. Biol. Chem. (2001)
- Detection and measurement of alpha-fetoprotein in human breast cancer cytosol after treatment with 0.4 M potassium chloride. Sarcione, E.J., Zloty, M., Delluomo, D.S., Mizejewski, G., Jacobson, H. Cancer Res. (1983)
- Alpha-fetoprotein stimulated the expression of some oncogenes in human hepatocellular carcinoma Bel 7402 cells. Li, M.S., Li, P.F., Chen, Q., Du, G.G., Li, G. World J. Gastroenterol. (2004)
- Susceptibility to killer T cells of gastric cancer cells enhanced by Mitomycin-C involves induction of ATBF1 and activation of p21 (Waf1/Cip1) promoter. Miura, Y., Kataoka, H., Joh, T., Tada, T., Asai, K., Nakanishi, M., Okada, N., Okada, H. Microbiol. Immunol. (2004)
- Effects of various substrates on human hepatoblastoma and hepatoma cell culture. Tokiwa, T., Miyagiwa, M., Kusaka, Y., Muraoka, A., Sato, J. Cell Biol. Int. Rep. (1988)
- The targeted expression of the human interleukin-2/interferon alpha2b fused gene in alpha-fetoprotein-expressing hepatocellular carcinoma cells. He, P., Tang, Z.Y., Liu, B.B., Ye, S.L., Liu, Y.K. J. Cancer Res. Clin. Oncol. (1999)
- Alpha-fetoprotein positively regulates cytochrome c-mediated caspase activation and apoptosome complex formation. Semenkova, L., Dudich, E., Dudich, I., Tokhtamisheva, N., Tatulov, E., Okruzhnov, Y., Garcia-Foncillas, J., Palop-Cubillo, J.A., Korpela, T. Eur. J. Biochem. (2003)
- ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines. Shen, H., Luan, F., Liu, H., Gao, L., Liang, X., Zhang, L., Sun, W., Ma, C. J. Cell. Mol. Med. (2008)
- Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Capurro, M., Wanless, I.R., Sherman, M., Deboer, G., Shi, W., Miyoshi, E., Filmus, J. Gastroenterology (2003)
- The molecular clock runs at different rates among closely related members of a gene family. Gibbs, P.E., Witke, W.F., Dugaiczyk, A. J. Mol. Evol. (1998)
- Immunocytochemical characterization of amniotic fluid macrophages in cases of fetal neural tube defects. Polgar, K., Abel, G., Laczko, J., Sipka, S., Papp, Z. Am. J. Clin. Pathol. (1987)
- Differentiation of human umbilical cord blood stem cells into hepatocytes in vivo and in vitro. Tang, X.P., Zhang, M., Yang, X., Chen, L.M., Zeng, Y. World J. Gastroenterol. (2006)