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Disease relevance of Datura


High impact information on Datura

  • The first of these areas is the Chumash and Yokuts Indian region of California, where polychrome paintings show designs similar to those visualized during the trance induced by decoctions of jimsonweed (Datura species) [5].
  • Selection of this carbohydrate-containing form of NB with Datura stramonium lectin, its susceptibility to digestion by endo-beta-galactosidase, and determination of the size of NBp glycopeptides by gel filtration chromatography suggested that the increase in molecular weight is due to processing to polylactosaminoglycan [6].
  • Western blot analysis revealed that binding of Datura stramonium agglutinin, which interacts with 2,6-branched tri- and tetra-antennary oligosaccharides, is significantly increased in several bands from MTAg compared with NIH3T3, two of which are tentatively identified as lysosome-associated membrane protein-1 and fibronectin (FN)-receptor [7].
  • To identify polylactosaminoglycan-containing glycoproteins, CaCo-2 cells were incubated with [3H]glucosamine or [3H]fucose, for 24 h, and membrane glycoproteins solubilized with 0.5% Nonidet P-40 were fractionated by affinity chromatography on Datura stramonium (DSA)-agarose [8].
  • Purification and characterization of O-acetylserine sulfhydrylase isoenzymes from Datura innoxia [9].

Biological context of Datura

  • In order to increase the production of the pharmaceuticals hyoscyamine and scopolamine in hairy root cultures, a binary vector system was developed to introduce the T-DNA of the Ri plasmid together with the tobacco pmt gene under the control of CaMV 35S promoter, into the genome of Datura metel and Hyoscyamus muticus [10].
  • The complete amino acid sequence of the respective [2Fe-2S] ferredoxins from two varieties of Datura stramonium, D. stramonium var. stramonium and D. stramonium var. tatula, have been determined by automated Edman degradation of the entire Cm-protein and of the peptides obtained by tryptic digestion and CNBr treatment [11].
  • The concentration-response curves and IC50 values were obtained and the respective relaxant potencies were compared with that of the CHCl3-MeOH (1:1) extract of Datura lanosa [12].
  • However, Datura plants in the same section (metel, fastuosa, and innoxia) and of different varieties (stramonium var. stramonium and stramonium var. tatula) showed identical Fd-cDNA nucleotide sequences [13].

Anatomical context of Datura


Associations of Datura with chemical compounds

  • It is shown by tracer experiments with DL-[2-3H,5-14C]- and DL-[(RS)-5-3H,5-14C]rnithine, that the metabolic conversion of ornithine into proline, in three plant species (Nicotiana tabacum, Datura stramonium, and Lupinus angustifolius), takes place with maintenance of the delta-hydrogen atoms but with loss of the alpha-hydrogen atom [19].
  • The authors warn physicians that intoxication by Angel's Trumpet (Datura sauveolens) is becoming more frequent due to its use by adolescents and young adults as a legal, readily available hallucinogen [20].
  • Oxidase-peroxidase enzymes of Datura innoxia. Oxidation of formylphenylacetic acid ethyl ester [21].
  • Some properties of the lectin from Datura stramonium (thorn-apple) and the nature of its glycoprotein linkages [22].
  • Oligosaccharides released from the two enzymes by hydrazinolysis were fractionated by paper electrophoresis, serial chromatographies on columns of immobilized Aleuria aurantia lectin, concanavalin A, phytohemagglutinin E4, and Datura stramonium agglutinin, and Bio-Gel P-4 (less than 400 mesh) column chromatography [23].

Gene context of Datura

  • Differentiation of F9 cells by retinoic acid increased labelling of all Datura stramonium-bound glycoproteins, including lamp-1 and lamp-2 [24].
  • In contrast, the behavior of rfaY mutants only differed from the wild type in Datura, a non-host plant in which the growth of the wild type is severely attenuated [25].
  • The successful infection of Datura stramonium plants and leaf discs of transgenic tobacco plants expressing VirE2 protein by an A. tumefaciens virE2 mutant carrying osa confirmed that oncogenic suppression by osa does not occur by blocking T-DNA transfer [26].
  • A cDNA for a plant ornithine decarboxylase (ODC), a key enzyme in putrescine and polyamine biosynthesis, has been isolated from root cultures of the solanaceous plant Datura stramonium [27].
  • Coma with focal neurological signs caused by Datura stramonium intoxication in a young man [28].

Analytical, diagnostic and therapeutic context of Datura


  1. Host and viral factors determine the dispensability of coat protein for bipartite geminivirus systemic movement. Pooma, W., Gillette, W.K., Jeffrey, J.L., Petty, I.T. Virology (1996) [Pubmed]
  2. Characterization of O-glycan moieties of the 210 and 240 kDa pig intestinal receptors for Escherichia coli K88ac fimbriae. Seignole, D., Grange, P., Duval-Iflah, Y., Mouricout, M. Microbiology (Reading, Engl.) (1994) [Pubmed]
  3. Expression of an antisense Datura stramonium S-adenosylmethionine decarboxylase cDNA in tobacco: changes in enzyme activity, putrescine-spermidine ratio, rhizogenic potential, and response to methyl jasmonate. Torrigiani, P., Scaramagli, S., Ziosi, V., Mayer, M., Biondi, S. J. Plant Physiol. (2005) [Pubmed]
  4. Fifteen cases of atropine poisoning after honey ingestion. Ramirez, M., Rivera, E., Ereu, C. Veterinary and human toxicology. (1999) [Pubmed]
  5. North American Indian rock art and hallucinogenic drugs. Wellmann, K.F. JAMA (1978) [Pubmed]
  6. Polylactosaminoglycan modification of a small integral membrane glycoprotein, influenza B virus NB. Williams, M.A., Lamb, R.A. Mol. Cell. Biol. (1988) [Pubmed]
  7. Increased expression of highly branched N-glycans at cell surface is correlated with the malignant phenotypes of mouse tumor cells. Asada, M., Furukawa, K., Segawa, K., Endo, T., Kobata, A. Cancer Res. (1997) [Pubmed]
  8. Decrease in polylactosaminoglycans associated with lysosomal membrane glycoproteins during differentiation of CaCo-2 human colonic adenocarcinoma cells. Youakim, A., Romero, P.A., Yee, K., Carlsson, S.R., Fukuda, M., Herscovics, A. Cancer Res. (1989) [Pubmed]
  9. Purification and characterization of O-acetylserine sulfhydrylase isoenzymes from Datura innoxia. Kuske, C.R., Ticknor, L.O., Guzmán, E., Gurley, L.R., Valdez, J.G., Thompson, M.E., Jackson, P.J. J. Biol. Chem. (1994) [Pubmed]
  10. Effect of pmt gene overexpression on tropane alkaloid production in transformed root cultures of Datura metel and Hyoscyamus muticus. Moyano, E., Jouhikainen, K., Tammela, P., Palazón, J., Cusidó, R.M., Piñol, M.T., Teeri, T.H., Oksman-Caldentey, K.M. J. Exp. Bot. (2003) [Pubmed]
  11. Protein chemotaxonomy of genus Datura: identical amino acid sequence of ferredoxin from two varieties of Datura stramonium. Mino, Y., Usami, H., Inoue, S., Ikeda, K., Ota, N. Phytochemistry (1993) [Pubmed]
  12. Spasmolytic activity of some plants used by the Otomi Indians of Quéretaro (México) for the treatment of gastrointestinal disorders. Rojas, A., Bah, M., Rojas, J.I., Serrano, V., Pacheco, S. Phytomedicine (1999) [Pubmed]
  13. Comparison of the nucleotide sequences of ferredoxin-cDNAs among some Datura plants. Mino, Y., Shirakawa, M., Harada, Y., Kuroda, K. Biol. Pharm. Bull. (2004) [Pubmed]
  14. Characterization of a novel family of ciliary body glycoproteins. Howell, D.N., Ross, J.R., Miller, S.E., Sanfilippo, F.P. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  15. Prostaglandin D2 generation by rat peritoneal mast cells stimulated with Datura stramonium agglutinin and its inhibition by haptenic sugar and wheat germ agglutinin. Suzuki-Nishimura, T., Uchida, M.K. Jpn. J. Pharmacol. (2002) [Pubmed]
  16. Poly-N-acetyllactosamine alterations of Thy-1 glycoprotein in lymphocyte differentiation. Morrison, M.H., Lynch, R.A., Esselman, W.J. Mol. Immunol. (1986) [Pubmed]
  17. Glycoconjugates of the human trabecular meshwork: a lectin histochemical study. Chapman, S.A., Bonshek, R.E., Stoddart, R.W., Jones, C.J., Mackenzie, K.R., O'Donoghue, E., Mcleod, D. Histochem. J. (1995) [Pubmed]
  18. Mucous domains: microchemical heterogeneity in the mucociliary complex of the olfactory epithelium. Getchell, T.V., Su, Z., Getchell, M.L. Ciba Found. Symp. (1993) [Pubmed]
  19. The biosynthetic route from ornithine to proline. Mestichelli, L.J., Gupta, R.N., Spenser, I.D. J. Biol. Chem. (1979) [Pubmed]
  20. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Hall, R.C., Popkin, M.K., Mchenry, L.E. The American journal of psychiatry. (1977) [Pubmed]
  21. Oxidase-peroxidase enzymes of Datura innoxia. Oxidation of formylphenylacetic acid ethyl ester. Kalyanaraman, V.S., Mahadevan, S., Kumar, S.A. Biochem. J. (1975) [Pubmed]
  22. Some properties of the lectin from Datura stramonium (thorn-apple) and the nature of its glycoprotein linkages. Desai, N.N., Allen, A.K., Neuberger, A. Biochem. J. (1981) [Pubmed]
  23. Comparative studies of the sugar chains of aminopeptidase N and dipeptidylpeptidase IV purified from rat kidney brush-border membrane. Yamashita, K., Tachibana, Y., Matsuda, Y., Katunuma, N., Kochibe, N., Kobata, A. Biochemistry (1988) [Pubmed]
  24. Lamp-1 does not acquire the large polylactosaminoglycans characteristic of F9 cells. Romero, P.A., Way, T., Herscovics, A. Biochem. J. (1993) [Pubmed]
  25. A locus determining pathogenicity of Xanthomonas campestris is involved in lipopolysaccharide biosynthesis. Dow, J.M., Osbourn, A.E., Wilson, T.J., Daniels, M.J. Mol. Plant Microbe Interact. (1995) [Pubmed]
  26. pSa causes oncogenic suppression of Agrobacterium by inhibiting VirE2 protein export. Lee, L.Y., Gelvin, S.B., Kado, C.I. J. Bacteriol. (1999) [Pubmed]
  27. Molecular cloning and functional identification of a plant ornithine decarboxylase cDNA. Michael, A.J., Furze, J.M., Rhodes, M.J., Burtin, D. Biochem. J. (1996) [Pubmed]
  28. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. Oberndorfer, S., Grisold, W., Hinterholzer, G., Rosner, M. J. Neurol. Neurosurg. Psychiatr. (2002) [Pubmed]
  29. Mydriasis from Datura wrightii. Reader, A.L. Am. J. Ophthalmol. (1977) [Pubmed]
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