- Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor. Windahl, S.H., Galien, R., Chiusaroli, R., Clément-Lacroix, P., Morvan, F., Lepescheux, L., Nique, F., Horne, W.C., Resche-Rigon, M., Baron, R. J. Clin. Invest. (2006)