Aliskiren: a renin inhibitor offering a new approach for the treatment of hypertension.
In recent years, the renin-angiotensin-aldosterone system has been shown to be crucial not only in blood pressure haemostasis but also in the evolution of atherosclerosis, which ultimately determines morbidity and mortality. The angiotensin-converting enzyme inhibitors and, recently, the angiotensin receptor blockers (with their low adverse-effect profile) have added a new dimension to the drug treatment of hypertension. Just a decade after the introduction of angiotensin receptor blockers, physicians treating hypertension are now offered another exciting approach to achieving blockade of the renin-angiotensin-aldosterone system through the inhibition of renin. This review outlines the background evidence for aliskiren, the first orally active renin inhibitor.[1]References
- Aliskiren: a renin inhibitor offering a new approach for the treatment of hypertension. O'Brien, E. Expert. Opin. Investig. Drugs (2006) [Pubmed]
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